Results 101 to 110 of about 28,615 (209)

mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy

Mediators of Inflammation
Sepsis has been the leading cause of death in ICU patients. CD4+ T cells are the mainstay of the body’s immune system, and the depletion of CD4+ T cells in sepsis is of great concern.
Xianli Lei, Guoyu Zhao, Yawen Xie, Na Cui   +3 more
doaj   +1 more source

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Neurobiology of Disease, 2015
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine ...
Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley   +7 more
doaj   +1 more source

RHEB1 Expression in Embryonic and Postnatal Mouse

, 2016
Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an ...
Clement, Joachim H, Danilchik, Michael V., Derkatch, Alex, Federov, Lev M., Marks, Daniel L., Schubert, Harald, Smart, James L., Tian, Qi, Wang, Yingming   +8 more
core  

Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment [PDF]

, 2018
Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND).
Mowrey, Kate
core   +1 more source

Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex [PDF]

, 2019
Tuberous sclerosis complex (TSC) is a neurogenetic disorder associated with epilepsy, intellectual disabilities, and autistic behaviors. These neurological symptoms result from synaptic dysregulations, which shift a balance between excitation and ...
A Banerjee, A Goel, A Ito-Ishida, A Kepecs, A Maffei, A Yoshii, Akira Yoshii, AL Dorrn, AW Buckley, B Chattopadhyaya, BV Atallah, C Dravet, C Fu, C Le Magueresse, C Tai, CA Hoeffer, D Ehninger, D Nie, D Vogt, DA Lewis, DD Sarbassov, DH Geschwind, DM Talos, E Asano, E Asano, G Silberberg, G Tang, GA Ascoli, H Adesnik, H Katagiri, H Markram, H Taniguchi, H Taniguchi, H-T Chao, HS Bateup, HS Bateup, I Mody, I Ogiwara, I Soltesz, J Noebels, Jian-Ping Zhao, JLR Rubenstein, K Krishnan, K Mori, K Staley, L Madisen, L Meikle, L Meikle, L-J He, M Rubinstein, M Xue, NR Wilson, O Marín, R Tremblay, S-H Lee, SB Dutton, SB Mierau, SB Nelson, SF Tavazoie, T Bourgeron, TK Hensch, TK Hensch, W Zhang, Y Yazaki-Sugiyama, YJ Choi, ZJ Huang, ZJ Huang   +66 more
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Adult reversal of cognitive phenotypes in neurodevelopmental disorders [PDF]

, 2009
Recent findings in mice suggest that it is possible to reverse certain neurodevelopmental disorders in adults. Changes in development, previously thought to be irrepa-rable in adults, were believed to underlie the neurological and psychiatric phenotypes ...
Alcino J. Silva, Dan Ehninger, D Ehninger, WB Hanley, J Rovet, RT Zoeller, AT Dugbartey, JD Davis, B Kolb, SJ Vannucci, W Li, Y Mao, AJ Silva, W Li, RM Costa, Y Cui, LC Krab, RH Reeves, AM Kleschevnikov, F Fernandez, N Rueda, TK Hensch, T Pizzorusso, JH Rubinstein, F Petrij, BE Lonze, TM Hallam, R Bourtchouladze, JM Alarcon, C Joinson, P Vries de, ECTS Consortium, M Slegtenhorst van, FJ O’Callaghan, A Raznahan, SM Goorden, D Ehninger, L Meikle, LH Zeng, DJ Marsh, A Goffin, MG Butler, CH Kwon, J Zhou, E Courchesne, RJ Hagerman, GJ Bassell, MF Bear, G Dolen, SM McBride, QJ Yan, FM Vrij de, FV Bolduc, SC Chuang, E Berry-Kravis, E Berry-Kravis, A Rett, RE Amir, M Chahrour, N Kishi, RZ Chen, J Guy, M Shahbazian, J Guy, VS Dani, JR Gibson, K Tabuchi, JL Rubenstein, A Sale, JF Maya Vetencourt   +69 more
core   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Mechanistic target of rapamycin (mTOR) activation during ruminant mammary development and function : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand [PDF]

, 2013
This thesis examines the abundance of total and activated mechanistic target of rapamycin (mTOR) pathway components in the developing and functional ruminant mammary gland. mTOR pathway activation is stimulated by a wide range of intra- and extracellular
Sciascia, Quentin Leon
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