Results 111 to 120 of about 28,615 (209)

Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia [PDF]

, 2012
Tuberous sclerosis (TS) is a common autosomal-dominant disorder characterized by tumors of the skin, lung, brain, and kidneys. Monotherapy with rapamycin however resulted in partial regression of tumors, implying the involvement of additional pathways ...
Abel, Martin-Garrido, Arbiser, Jack L, Band, Hamid, Bonner, Michael Y., Chen, Suephy, Curatolo, Adam S, Govindarajan, Baskaran, Moses, Marsha, Veledar, Emir, Willoughby, Laura   +9 more
core   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Variants within TSC2 exons 25 and 31 are very unlikely to cause clinically diagnosable tuberous sclerosis [PDF]

, 2016
Inactivating mutations in TSC1 and TSC2 cause tuberous sclerosis complex (TSC). The 2012 international consensus meeting on TSC diagnosis and management agreed that the identification of a pathogenic TSC1 or TSC2 variant establishes a diagnosis of TSC ...
Dawson, NL, Ekong, R, Emmett, W, Futema, M, Humphries, SE, Plagnol, V, Povey, MS   +6 more
core  

A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS [PDF]

, 2014
Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signaling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive ...
Alexander, Angela, Cai, Shengli, Dere, Ruhee, Di Nardo, Alessia, Dodd, Kayleigh M., Dunlop, Elaine A., Faust, Phyllis L., Folkerth, Rebecca D., Han, Juliette M., Kastan, Michael B., Kim, Jinhee, Kwiatkowski, Erica, Sahin, Mustafa, Tait-Mulder, Jacqueline, Tee, Andrew R., Tripathi, Durga Nand, Walker, Cheryl Lyn, Zhang, Jiangwei   +17 more
core   +1 more source

Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 4, Page 257-269, June 2026.
ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra, Tin‐Suet Joan Lee, Jacob Vorstman, Patricia Parkin, Louise Gallagher, Aneta Krakowski   +5 more
wiley   +1 more source

Renal cell carcinoma in tuberous sclerosis complex [PDF]

, 2014
Renal cell carcinoma (RCC) occurs in 2% to 4% of patients with tuberous sclerosis complex (TSC). Previous reports have noted a variety of histologic appearances in these cancers, but the full spectrum of morphologic and molecular features has not been ...
Cheng, Liang, Cornejo, Kristine M., Feldman, Adam S., Henske, Elizabeth P., Jiang, Zhong, Jozwiak, Sergiusz, Kwiatkowski, David J., Nussbaum, Robert L., Oliva, Esther, Paul, Elahna, Sadow, Peter M., Thiele, Elizabeth A., Wang, Mingsheng, Wu, Chin-Lee, Xiao, Yu, Yang, Ping, Young, Robert H., Yu, Jane J.   +17 more
core   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.

PLoS Biology, 2019
Dendritic cells (DCs) play pivotal roles in T-cell homeostasis and activation, and metabolic programing has been recently linked to DC development and function.
Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao   +13 more
doaj   +1 more source