Results 91 to 100 of about 36,256,275 (202)

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference [PDF]

, 2016
On March 10 to March 12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland, to assess progress and new opportunities for research in tuberous sclerosis complex
Darling, Thomas N, Pende, Mario, Thiele, Elizabeth, Ess, Kevin C, Bissler, John J, Nelson, Charles A, Chugani, Diane C, Wu, Joyce Y, Kwiatkowski, David J, Wagner, Andrew J, D'Arcangelo, Gabriella, Murphy, Leon O, Blenis, John, Moss, Joel, Franz, David, Nellist, Mark, St. Hillaire-Clarke, Coryse, de Vries, Petrus J, Klitgaard, Henrik, Klann, Eric, Paul, Elahna, Rosbeck, Kari Luther, Henske, Elizabeth P, Manning, Brendan D, Zervas, Mark, Song, Minkyung H, Weiner, Howard L, Perrimon, Norbert, Sahin, Mustafa, Young, Lisa R, Krueger, Darcy, Northrup, Hope, Crino, Peter B, Wong, Michael, Silva, Alcino J, Cichowski, Karen, Mamounas, Laura A, Long, Cara, Der, Channing, Bebin, E Martina, Gambello, Michael J, Shaw, Reuben J, Rieff, Heather, Roberds, Steven L, Byars, Anna W, Fureman, Brandy E, Macklin, Wendy B, Krymskaya, Vera P, Plan, Tuberous Sclerosis Complex Working Group to Update the Research   +48 more
core   +1 more source

Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis [PDF]

, 2012
Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but more than 50 MS loci of modest effect ...
Giovannoni G, Sotgiu, S, Giulio Disanto, SOTGIU, Stefano, Giulio Disanto (125817), Gavin Giovannoni, Ragnedda, G, George C. Ebers (125822), Stefano Sotgiu (125824), Disanto, Giulio, Ramagopalan SV, Giammario Ragnedda, George C Ebers, Ebers, George C., Ebers, George, Giammario Ragnedda (125814), Gavin Giovannoni (125820), Giovannoni Gavin, Ramagopalan Sreeram V., Sotgiu Stefano, Ramagopalan, SV, RAGNEDDA, GIammario, Stefano Sotgiu, Sreeram V. Ramagopalan (125826), Ramagopalan, Sreeram, Ragnedda Giammario, Sreeram V Ramagopalan, Disanto Giulio, Ebers, GC, Giovannoni, Gavin, Ramagopalan, Sreeram V., Ebers GC, Ebers George C., Giovannoni, G, Disanto G, Disanto, G   +35 more
core   +1 more source

Expression of the anti-apoptotic protein survivin amd altered function of IGF-1 pathway in TSC2 brain tubers

, 2007
Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome characterized by multiorgan development of benign and occasional malignant tumors. The neurological manifestations include epilepsy, developmental delay, mental retardation, and autism ...
V. Grande, M.P. Canevini, L. Madaschi, E. Isaia, E. Lesma, L. Tassi, A.M. Di Giulio, A. Gorio   +7 more
core   +2 more sources

The effect of a bout of resistance exercise on skeletal muscle protein metabolism after severe fasting

Physiological Reports, 2019
Resistance exercise (RE) activates the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway and increases muscle protein synthesis. Severe fasting induces 5′ adenosine monophosphate‐activated protein kinase (AMPK), which attenuates mTORC1
Kohei Sase, Kohei Kido, Satoru Ato, Satoshi Fujita   +3 more
doaj   +1 more source

Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter

Case Reports in Oncology, 2018
We evaluated the efficacy of everolimus in 3 patients who had huge renal angiomyolipomas associated with tuberous sclerosis complex. Two patients with large lipid-rich angiomyolipomas had a history of renal transarterial embolization for renal bleeding ...
Naoya Toriu, Hiroki Mizuno, Naoki Sawa, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Akinari Sekine, Masayuki Yamanouchi, Junichi Hoshino, Kenmei Takaichi, Motoko Yanagita, Takuya Fujimaru, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Yoshifumi Ubara   +15 more
doaj   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy

Mediators of Inflammation
Sepsis has been the leading cause of death in ICU patients. CD4+ T cells are the mainstay of the body’s immune system, and the depletion of CD4+ T cells in sepsis is of great concern.
Xianli Lei, Guoyu Zhao, Yawen Xie, Na Cui   +3 more
doaj   +1 more source

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Neurobiology of Disease, 2015
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine ...
Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley   +7 more
doaj   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA [PDF]

, 2012
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA).
Das, Rita, Maniatis, Tom, Sharma, A, Yan, Biao, Tapia, JC, Gygi, Steve P., Monica A. Carrasco, Shneider, NA, Nishimura, AL, Chen, Shi, Yu, Yong, Sharma, Aarti, Yan, B, Gygi, SP, Christopher E. Shaw, Yamazaki, T, Steve P. Gygi, Siddharthan Chandran, Reed, Robin, Yu, Y, Aarti Sharma, Reed, R, Yong Yu, Rita Das, Das, R, Carrasco, Monica A., Zhai, Bo, Shneider, Neil A., Chen, S, Juan C. Tapia, Tapia, Juan C., Agnes Lumi Nishimura, Lalancette-Hebert, Melanie, Haertlein, TC, Tom Maniatis, Lalancette-Hebert, M, Biao Yan, Carrasco, MA, Neil A. Shneider, Yamazaki, Tomohiro, Nishimura, Agnes Lumi, Sullivan, G, Maniatis, T, Shaw, Christopher E., Shi Chen, Zhai, B, Melanie Lalancette-Hebert, Sullivan, Gareth, Tyler C. Haertlein, Shaw, CE, Chandran, S, Haertlein, Tyler C., Tomohiro Yamazaki, Gareth Sullivan, Robin Reed, Bo Zhai, Chandran, Siddharthan   +56 more
core   +1 more source