Results 71 to 80 of about 23,821 (165)

Variants of TSC1 are associated with developmental and epileptic encephalopathy and focal epilepsy without tuberous sclerosis

Acta Epileptologica
The TSC1 gene encodes a growth inhibitory protein hamartin, which plays a crucial role in negative regulation of the activity of mTORC1 (mechanistic target of rapamycin complex 1). TSC1 has been associated with tuberous sclerosis complex (TSC).
Nanxiang Shen, Zhihong Zhuo, Xiangyun Luo, Bing-Mei Li, Xuqing Lin, Sheng Luo, Zilong Ye, Peng-Yu Wang, Na He, Yiwu Shi, Weiping Liao   +10 more
semanticscholar   +1 more source

mTOR Deletion Alleviates CD4+ T-Cell Dysfunction in Sepsis through Reducing CTLA4 Accumulation Mediated by Rescuing Autophagy

Mediators of Inflammation
Sepsis has been the leading cause of death in ICU patients. CD4+ T cells are the mainstay of the body’s immune system, and the depletion of CD4+ T cells in sepsis is of great concern.
Xianli Lei, Guoyu Zhao, Yawen Xie, Na Cui   +3 more
doaj   +1 more source

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Neurobiology of Disease, 2015
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine ...
Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley   +7 more
doaj   +1 more source

Genetically-engineered human cortical spheroid models of Tuberous Sclerosis

Nature Medicine, 2018
Tuberous sclerosis complex (TSC) is a multisystem developmental disorder caused by mutations in the TSC1 or TSC2 genes, whose protein products are negative regulators of mechanistic target of rapamycin complex 1 signaling. Hallmark pathologies of TSC are
J. Blair, D. Hockemeyer, Helen S. Bateup
semanticscholar   +1 more source

The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma

British Journal of Cancer, 2019
Despite significant advances in the understanding of glioblastoma genetics and biology, survival is still poor. Hypoxia and nutrient depletion in the tumour microenvironment induce adaptive signalling and metabolic responses, which can influence ...
M. Foltyn, A. Luger, Nadja I. Lorenz, Benedikt Sauer, M. Mittelbronn, P. Harter, J. Steinbach, M. Ronellenfitsch   +7 more
semanticscholar   +1 more source

TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis.

PLoS Biology, 2019
Dendritic cells (DCs) play pivotal roles in T-cell homeostasis and activation, and metabolic programing has been recently linked to DC development and function.
Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao   +13 more
doaj   +1 more source

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling

Frontiers in Molecular Neuroscience, 2017
Mania causes symptoms of hyperactivity, impulsivity, elevated mood, reduced anxiety and decreased need for sleep, which suggests that the dysfunction of the striatum, a critical component of the brain motor and reward system, can be causally associated ...
Yeunkum Lee, Yeunkum Lee, Sun Gyun Kim, Bokyoung Lee, Yinhua Zhang, Yinhua Zhang, Yoonhee Kim, Shinhyun Kim, Shinhyun Kim, Eunjoon Kim, Eunjoon Kim, Hyojin Kang, Kihoon Han, Kihoon Han   +13 more
doaj   +1 more source

Death-associated protein kinase 1: a double-edged sword in health and disease

Frontiers in Immunology
Death-associated protein kinase 1 (DAPK1) is a Ca2+/calmodulin-regulated serine/threonine kinase that orchestrates a wide array of cellular activities.
Xiuli Zhang, Yehuda G. Assaraf, Yao Lin
doaj   +1 more source

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

Proceedings of the National Academy of Sciences of the United States of America, 2002
Andrew R. Tee, D. Fingar, B. Manning, D. Kwiatkowski, L. Cantley, J. Blenis   +5 more
semanticscholar   +1 more source

Mammalian target of rapamycin complex 1 (mTORC1); tuberous sclerosis complex tumor suppressors 1 and 2 (TSC1 and TSC2); unfolded protein response (UPR) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source