Results 81 to 90 of about 31,123,995 (208)

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways.

The Journal of biological chemistry, 2004
Tuberin (TSC2) is a tumor suppressor gene. At the cellular level, tuberin is required as a critical regulator of cell growth, neuronal differentiation, and tumor suppression. Here we report a critical role for tuberin in late stage myeloid cell differentiation.
Maria C, Birchenall-Roberts, Tao, Fu, Ok-Sun, Bang, Michael, Dambach, James H, Resau, Cari L, Sadowski, Daniel C, Bertolette, Ho-Jae, Lee, Seong-Jin, Kim, Francis W, Ruscetti   +9 more
openaire   +1 more source

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Neurobiology of Disease, 2015
Autophagy is a fundamental cellular recycling process vulnerable to compromise in neurodegeneration. We now report that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine ...
Marni E. Harris-White, Kathie G. Ferbas, Ming F. Johnson, Pirooz Eslami, Aleksandra Poteshkina, Kalina Venkova, Alexandar Christov, Kenneth Hensley   +7 more
doaj   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference [PDF]

, 2016
On March 10 to March 12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland, to assess progress and new opportunities for research in tuberous sclerosis complex
Darling, Thomas N, Pende, Mario, Thiele, Elizabeth, Ess, Kevin C, Bissler, John J, Nelson, Charles A, Chugani, Diane C, Wu, Joyce Y, Kwiatkowski, David J, Wagner, Andrew J, D'Arcangelo, Gabriella, Murphy, Leon O, Blenis, John, Moss, Joel, Franz, David, Nellist, Mark, St. Hillaire-Clarke, Coryse, de Vries, Petrus J, Klitgaard, Henrik, Klann, Eric, Paul, Elahna, Rosbeck, Kari Luther, Henske, Elizabeth P, Manning, Brendan D, Zervas, Mark, Song, Minkyung H, Weiner, Howard L, Perrimon, Norbert, Sahin, Mustafa, Young, Lisa R, Krueger, Darcy, Northrup, Hope, Crino, Peter B, Wong, Michael, Silva, Alcino J, Cichowski, Karen, Mamounas, Laura A, Long, Cara, Der, Channing, Bebin, E Martina, Gambello, Michael J, Shaw, Reuben J, Rieff, Heather, Roberds, Steven L, Byars, Anna W, Fureman, Brandy E, Macklin, Wendy B, Krymskaya, Vera P, Plan, Tuberous Sclerosis Complex Working Group to Update the Research   +48 more
core   +1 more source

IL-37d suppresses Rheb-mTORC1 axis independently of TCS2 to alleviate alcoholic liver disease

Communications Biology
Tuberous sclerosis complex 2 (TSC2) crucially suppresses Rheb activity to prevent mTORC1 activation. However, mutations in TSC genes lead to mTORC1 overactivation, thereby causing various developmental disorders and cancer.
Nuo Chen, Xiaoyu Wang, Yaxin Guo, Ming Zhao, Baihui Cao, Bing Zhan, Yubin Li, Tian Zhou, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Lining Zhang, Yan Li   +13 more
doaj   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Investigation of the effects of different mTOR inhibitors on protein synthesis

, 2011
The mammalian target of rapamycin (mTOR), which controls diverse cellular processes, is regulated by the integration of many signals. Rapamycin strongly inhibits the proliferation of many cancer cell lines and there is a high level of interest in its ...
Huo, Yilin
core   +1 more source

Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium

Frontiers in Pharmacology, 2020
Immune memory has a protective effect on the human body, but abnormal immune memory is closely related to the occurrence and development of autoimmune diseases including inflammatory bowel disease (IBD).
Wei Ge, Hai-Yan Wang, Hai-Mei Zhao, Xue-Ke Liu, You-Bao Zhong, Jian Long, Zheng-Yun Zuo, Duan-Yong Liu, Duan-Yong Liu   +8 more
doaj   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Optimal management of seizures associated with tuberous sclerosis complex: current and emerging options [PDF]

, 2014
Shelly Wang,1 Aria Fallah2,3 1Department of Neurosurgery, University of Toronto, Toronto, ON, Canada; 2Department of Neurosurgery, Miami Children’s Hospital, Miami, FL, USA; 3Department of Clinical Epidemiology and Biostatistics, McMaster ...
Wang, Shelly, Wang S, Fallah, Aria, Fallah A   +3 more
core   +1 more source