Results 101 to 110 of about 28,506 (225)

Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium

Frontiers in Pharmacology, 2020
Immune memory has a protective effect on the human body, but abnormal immune memory is closely related to the occurrence and development of autoimmune diseases including inflammatory bowel disease (IBD).
Wei Ge, Hai-Yan Wang, Hai-Mei Zhao, Xue-Ke Liu, You-Bao Zhong, Jian Long, Zheng-Yun Zuo, Duan-Yong Liu, Duan-Yong Liu   +8 more
doaj   +1 more source

Chronic sleep deprivation promotes drug‐resistant epilepsy via the BMAL1‐mTOR‐P‐gp axis

Epilepsia Open, EarlyView.
Abstract Objective The interplay between chronic sleep deprivation and drug‐resistant epilepsy (DRE) has gained increasing attention. Brain and muscle Arnt‐like protein 1 (BMAL1), which is implicated in sleep disturbance, has an unclear role in DRE. We aimed to investigate the role of BMAL1 in sleep deprivation‐induced DRE. Methods A pentylenetetrazole
Xiaomeng Wang, Rui Li, Yuzhu Zhang, Yi Hu, Jingjiao Chen, Sijia Tian, Dong Zhou, Xiaosa Chi   +7 more
wiley   +1 more source

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex [PDF]

, 2014
The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues.
Halley, D.J.J. (Dicky), Hoogeveen-Westerveld, M. (Marianne), Kikkawa, U. (Ushio), Maat-Kievit, A.A. (Anneke), Nakashima, A. (Akio), Nellist, M.D. (Mark), Ouweland, A.M.W. (Ans) van den, Santiago Lima, A.J. (Arthur Jorge)   +7 more
core   +1 more source

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

JSFA reports, EarlyView.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem, Khurram Afzal, Asad Abbas, Talha Bin Iqbal, Abdul Malik, Javaria Saeed, Mutjardah Zarrish, Bipindra Pandey   +7 more
wiley   +1 more source

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

Psychiatric Impact of Tuberous Sclerosis Complex and Utilization of Mental Health Treatment [PDF]

, 2018
Tuberous sclerosis complex (TSC) is a multi-system, neurocutaneous disorder with neuropsychiatric features known as TSC-associated neuropsychiatric disorders (TAND).
Mowrey, Kate
core   +1 more source

Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex [PDF]

, 2019
Tuberous sclerosis complex (TSC) is a neurogenetic disorder associated with epilepsy, intellectual disabilities, and autistic behaviors. These neurological symptoms result from synaptic dysregulations, which shift a balance between excitation and ...
A Banerjee, A Goel, A Ito-Ishida, A Kepecs, A Maffei, A Yoshii, Akira Yoshii, AL Dorrn, AW Buckley, B Chattopadhyaya, BV Atallah, C Dravet, C Fu, C Le Magueresse, C Tai, CA Hoeffer, D Ehninger, D Nie, D Vogt, DA Lewis, DD Sarbassov, DH Geschwind, DM Talos, E Asano, E Asano, G Silberberg, G Tang, GA Ascoli, H Adesnik, H Katagiri, H Markram, H Taniguchi, H Taniguchi, H-T Chao, HS Bateup, HS Bateup, I Mody, I Ogiwara, I Soltesz, J Noebels, Jian-Ping Zhao, JLR Rubenstein, K Krishnan, K Mori, K Staley, L Madisen, L Meikle, L Meikle, L-J He, M Rubinstein, M Xue, NR Wilson, O Marín, R Tremblay, S-H Lee, SB Dutton, SB Mierau, SB Nelson, SF Tavazoie, T Bourgeron, TK Hensch, TK Hensch, W Zhang, Y Yazaki-Sugiyama, YJ Choi, ZJ Huang, ZJ Huang   +66 more
core   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

RHEB1 Expression in Embryonic and Postnatal Mouse

, 2016
Ras homolog enriched in brain (RHEB1) is a member within the superfamily of GTP-binding proteins encoded by the RAS oncogenes. RHEB1 is located at the crossroad of several important pathways including the insulin-signaling pathways and thus plays an ...
Clement, Joachim H, Danilchik, Michael V., Derkatch, Alex, Federov, Lev M., Marks, Daniel L., Schubert, Harald, Smart, James L., Tian, Qi, Wang, Yingming   +8 more
core  

Molecular genetics of intellectual disability [PDF]

, 2012
The goal of this chapter is to review the current knowledge of the genetic causes of intellectual disability, focusing on alterations at the chromosomal and single gene level, with particular mention to the new technological developments, including ...
Bessa, C., Lopes, Fátima, Maciel, P.
core   +2 more sources