Results 121 to 130 of about 31,123,995 (208)

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, Volume 38, Issue 56, 8 October 2026.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Pan‐Cancer Analysis of the Immunomodulatory Roles and Prognostic Value of PDXP and Experimental Verification in SKCM

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Multiple public databases, including TCGA, GEO, and TARGET, were utilized to comprehensively analyze pyridoxal phosphatase (PDXP) expression profiles across 34 cancer types. We further explored the associations of PDXP expression with clinicopathological features, tumor immune microenvironment, genomic heterogeneity, functional signaling ...
Yingjian Hu, Xinzhu Zeng, Wei Cao, Jianhao Jiao, Yuan Zhao, Jun Wang   +5 more
wiley   +1 more source

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease

Journal of Translational Medicine
Background Parkinson's disease (PD) is a sporadic neurodegenerative disorder with a rising incidence. Environmental toxins are considered the main etiological factor.
Xiaomei Liang, Yaqi Zeng, Piao Zhang, Baoyu Zhu, Jiezhu Feng, Tongtong Deng, Zhongling Fu, Chengshuai Liu, Chengyu Chen, Yuhu Zhang   +9 more
doaj   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

Cannabidiol in Adults With Lennox–Gastaut Syndrome: Real‐World Experience

European Journal of Neurology, Volume 33, Issue 10, October 2026.
Cannabidiol showed sustained effectiveness and good tolerability in adults with LGS, with high retention over a median follow‐up of 41 months. Treatment was associated with improvement in seizure burden, increased seizure‐free days, fewer seizure‐related hospital admissions, and caregiver‐reported improvement in cognitive and behavioural functioning ...
Pyae Aung, Debbie Miller, Emily Sewell, Laura Mantoan Ritter, Evangelia Theochari, Ioannis Stavropoulos, Robert Delamont, Mark P. Richardson, Joel S. Winston, Lina Nashef   +9 more
wiley   +1 more source

Tuberous Sclerosis Complex Presenting as Periungual Fibromas: A Rare Case Report and Literature Review [PDF]

Ying Li,1,* Zhipeng Wang,1,* Yanhua Yang,2 Xiaoyan Xu3 1Department of Pathology, Sanya Central Hospital (The Third People’s Hospital of Hainan Province), Sanya, 572000, People’s Republic of China; 2Department of Pathology, Qingdao Municipal ...
Li Y, Yang Y, Xu X, Wang Z
core  

Hepatopancreatic Vitellogenin Regulation in Marsupenaeus japonicus: Transcriptome Based on Endogenous Variation in Vitellogenin Expression Levels

Arthropoda
In penaeids, the major yolk protein precursor vitellogenin is synthesized in both the hepatopancreas and the ovary. While ovarian vitellogenin expression is clearly regulated by hormones from the X-organ/sinus gland in the eyestalk, regulation in the ...
Azreen Syazana Nazaruddin, Marwa Said El-Desoky, Yoji Igarashi, Kazutoshi Yoshitake, Makoto Kakinuma, Naoaki Tsutsui   +5 more
doaj   +1 more source

Implementing a Multidisciplinary Approach to Treating Tuberous Sclerosis Complex

, 2017
Objective: Tuberous sclerosis complex is expressed throughout the body, resulting in a range of clinical manifestations that can be challenging to manage.
Tanjala T. Gipson, Andrea Poretti
core   +1 more source

TSC2 gene characterization and mechanism of ammonia nitrogen stress inhibiting growth through AMPK/mTOR pathway mediated by TSC2 in Megalobrama amblycephala

Aquaculture Reports
This study was performed to evaluate the role of TSC2 (tuberous sclerosis complex 2) in the regulation of growth inhibition of fish exposed to chronic ammonia nitrogen.
Xiangyang Yuan, Qian Wang, Mengyang Dai, Hengjie Wang, Xinyu Xiong, Liang Pan, Canli Wang   +6 more
doaj   +1 more source

Expression of the anti-apoptotic protein survivin amd altered function of IGF-1 pathway in TSC2 brain tubers

, 2007
Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome characterized by multiorgan development of benign and occasional malignant tumors. The neurological manifestations include epilepsy, developmental delay, mental retardation, and autism ...
V. Grande, M.P. Canevini, L. Madaschi, E. Isaia, E. Lesma, L. Tassi, A.M. Di Giulio, A. Gorio   +7 more
core   +2 more sources