Results 141 to 150 of about 18,866 (220)

Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice

Genes and Diseases
Naked cuticle homolog 2 (NKD2) has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor. The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully understood.
Liying Shan, Xiaoxia Liao, Xiaoli Yang, Endong Zhu, Hairui Yuan, Jie Zhou, Xiaoxia Li, Baoli Wang   +7 more
doaj   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, Volume 88, Issue 7, Page 1315-1323, June 2026.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Mammalian target of rapamycin complex 1 (mTORC1); tuberous sclerosis complex tumor suppressors 1 and 2 (TSC1 and TSC2); unfolded protein response (UPR) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Characterization of a Variant of Tuberous Sclerosis Complex 2 and its Interaction with Rheb

, 2018
Protein-protein interactions are vital in maintaining proper function and homeostasis in cells. Some signaling pathways are regulated by G-proteins that work like switches to activate and deactivate pathways.
Sivakumar, Sowmya
core  

ANTI TUMOR ACTIVITY OF PCDNA3.1-TUBEROUS a COMPLEX-2 SENSE IN A HUMAN ORAL TONGUE CANCER (SP-C1) CELL LINE: AKTIVITAS ANTI TUMOR PCDNA3.1-TUBEROUS SCLEROTIC COMPLEX-2 SENSE PADA SEL KANKER LIDAH MANUSIA (SP-C1)

, 2012
Tuberous sclerosis complex (TSC) is a hamartomatous disease with defects in tuberin (TSC2) that can be autosomaldominant inheritance or spontaneous mutation.
Supriatno
core  

In vitro study of TSC1 deficiency in preadipocytes: insights into development and treatment options for tuberous sclerosis related lipomatosis. [PDF]

Orphanet J Rare Dis
Friedrich JE, Hentschel J, Richter S, Kiep H, Arélin M, Platzer K, Schulz T, Merkenschlager A, Kiess W, Mayer S, Jamra RA, Duc DL, Garten A, Kirstein AS.   +13 more
europepmc   +1 more source

Characterization of a Tuberous Sclerosis Complex 2 Variant and its Interaction Involving the Ras-Related Protein Rheb

, 2017
Structure-function relationships of any complex underlie the molecular details of the biological interactions. Rheb, Ras Homology Enriched in Brain, is a Ras-related protein, and it is genetically identified as a molecular switch.
Shokr, Nosaiba
core  

Genotypic and phenotypic features of 23 Egyptian patients with tuberous sclerosis complex. [PDF]

BMC Pediatr
Othman AA, Sadek AA, Aladawy MA, Aziz SP, Sedky A, Mansour TMM, Younis MMS, Abdelatif RG, Hassan AEM, Aboelmagd MA, Mohamed M, Mohamed KR, Elkousy SM, Montaser Elkady NM, Khang R, Ryu SW, Abdelkreem E.   +16 more
europepmc   +1 more source

Tuberous sclerosis complex with multisystem involvement: A case report. [PDF]

J Int Med Res
Chen H, Shi M, Yu Y, Zhang Z, Du Z.
europepmc   +1 more source

A case of giant renal angiomyolipoma and diabetic nephropathy with abnormalities in the genes TSC2 and HNF1B. [PDF]

CEN Case Rep
Sugimoto H, Sawa N, Oba Y, Mizuno H, Sekine A, Yamanouchi M, Tanaka K, Hasegawa E, Suwabe T, Wada T, Yokoyama T, Miki K, Nakamura Y, Ishii Y, Kono K, Ohashi K, Takazawa Y, Fujimaru T, Mori T, Sohara E, Ubara Y.   +20 more
europepmc   +1 more source