Results 171 to 180 of about 420,141 (304)

Tubulin [PDF]

, 2014

openalex   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity. [PDF]

Elife
Bisht A, Pippadpally S, Majumder S, Gopi AT, Das A, Sahi C, Ramaswami M, Kumar V.   +7 more
europepmc   +1 more source

Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics

, 2023
James M. Wagstaff, Vicente J. Planelles-Herrero, Grigory Sharov, Aisha Alnami, Frank Kozielski, Emmanuel Derivery, Jan Löwe   +6 more
openalex   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

Inhibition of Sterol Biosynthesis Alters Tubulin Association with Detergent-Insoluble Membranes and Affects Microtubule Organization in Pollen Tubes of <i>Nicotiana tabacum</i> L. [PDF]

Plants (Basel)
Onelli E, Maneta-Peyret L, Moreau P, Stroppa N, Berno V, Cammarota E, Caccianiga M, Gianfranceschi L, Moscatelli A.   +8 more
europepmc   +1 more source

Tubulin functions in early development probed by single isotype CRISPR-Cas9 knockouts [PDF]

Amir Sams, Tyler Bruno, Jeffrey M. Moore, Benjamin Feldman, Dan L. Sackett   +4 more
openalex   +1 more source

Pathway Leading to Correctly Folded β-Tubulin [PDF]

, 1996
Guoling Tian, Yi Huang, Heidi Rommelaere, Joël Vandekerckhove, Christophe Ampè, Nicholas J. Cowan   +5 more
openalex   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Peptide-based covalent inhibitor of tubulin detyrosination promotes mesenchymal-to-epithelial transition in lung cancer cells. [PDF]

Proc Natl Acad Sci U S A
Impheng H, Gillard G, Numnoi N, Feral A, Simon M, Louet M, Amblard M, Juge F, Vezenkov L, Rogowski K.   +9 more
europepmc   +1 more source