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Tumefactive demyelinating lesions versus CNS neoplasms, a comparative study
Multiple Sclerosis and Related Disorders, 2023Differentiating tumefactive demyelinating lesions (TDL) from neoplasms of the central nervous system continues to be a diagnostic dilemma in many cases.Our study aimed to examine and contrast the clinical and radiological characteristics of TDL, high-grade gliomas (HGG) and primary CNS lymphoma (CNSL).This was a retrospective review of 66 patients (23 ...
Sin Hong Chew +10 more
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Tumefactive demyelinating lesion
2018Clinical History: 45-year old man with 7 year history of dysarthria presented in 2018 with clinical worsening. Past MRI showed multiple brain lesions, biopsy showed no tumor cells but was otherwise inconclusive. LP was negative for oligoclonal bands. The patient was diagno...
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Tumefactive demyelination and glioblastoma: a rare collision lesion
Clinical Neuropathology, 2011Inflammatory demyelination occasionally forms a solitary mass lesion clinically and radiographically indistinguishable from glioma, replete with enhancement and mass effect. Termed "tumefactive demyelination" it often prompts a brain biopsy.We undertook neuroimaging and morphologic analysis of a unifocal demyelinating lesion intimately associated with ...
S F, Roemer +3 more
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Spectroscopic magnetic resonance imaging of a tumefactive demyelinating lesion
Neuroradiology, 2002Tumefactive demyelinating lesions can present with features similar, clinically and radiologically, to those of brain tumours. Proton MR spectroscopy has been increasingly used to characterize intracranial pathology. As the underlying pathophysiology of neoplasms is different from that of demyelinating disease, one may expect the metabolic composition ...
M, Law, D E, Meltzer, S, Cha
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Tumefactive demyelinating lesions: conventional and advanced magnetic resonance imaging
Multiple Sclerosis Journal, 2005In rare instances, demyelinating disorders present with radiological features that mimic a brain tumour. This often leads to biopsy, which-apart from carrying significant morbidity-frequently turns out as nondiagnostic or dispensable. We therefore set out to assess the contribution of repeated conventional magnetic resonance imaging (MRI), 1H-MR ...
Christian, Enzinger +5 more
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Multiple Sclerosis Journal, 2012
Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory and immunoregulatory cytokine involved in the pathogenesis of several autoimmune disorders. Etanercept, a TNF-α antagonist (anti-TNF-α) acting as a soluble TNF-α receptor, has been associated with neurological demyelinating disorders.
C W, Cereda +6 more
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Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory and immunoregulatory cytokine involved in the pathogenesis of several autoimmune disorders. Etanercept, a TNF-α antagonist (anti-TNF-α) acting as a soluble TNF-α receptor, has been associated with neurological demyelinating disorders.
C W, Cereda +6 more
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Bilateral Demyelinating Tumefactive Lesions in Three Children With Hemiparesis
Journal of Child Neurology, 2002We present the results from the evaluations of three children ages of 2, 7, and 11 years with hemiparesis and multiple white-matter lesions on magnetic resonance images (MRIs). The initial symptoms were mainly acute/subacute hemiparesis in all and headache/vomiting in one of them.
Zuhal, Yapici, Mefkure, Eraksoy
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[Tumefactive Demyelinating Lesions].
Brain and nerve = Shinkei kenkyu no shinpoTumefactive demyelinating lesions (TDL), defined as inflammatory demyelinating lesions, may develop either during treatment for multiple sclerosis and related disorders or as the first demyelinating episode without any past medical history suggesting demyelination. If the latter, it would be so delicate to diagnose as demyelination.
Yuki, Mizumoto, Tetsuya, Abe
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Proton MR spectroscopy of tumefactive demyelinating lesions.
AJNR. American journal of neuroradiology, 2003Tumefactive demyelinating lesions (TDLs) can simulate intracranial neoplasms in clinical presentation and MR imaging appearance, and surgical biopsy is often performed in suspected tumors. Proton MR spectroscopy has been applied in assessing various intracranial diseases and is increasingly used in diagnosis and clinical management.
Amit M, Saindane +5 more
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Tumefactive demyelinating lesions in paediatric population
Purpose Methods and materials Results Conclusion Personal information and conflict of interest ...openaire +1 more source