Results 251 to 260 of about 127,911,481 (277)

Recapitulation of dynamic nanoparticle transport around tumors using a triangular multi-chamber tumor-on-a-chip.

Lab on a Chip, 2022
3D tumor models are emerging as valuable tools for drug screening and nanoparticle based personalized cancer treatments. The main challenges in building microfluidic chip-based 3D tumor models currently include the development of bioinks with high ...
You Chen, Yi-Fan Xue, Langtao Xu, Weilin Li, Yi-Ling Chen, Shunan Zheng, Rui Dai, Jie Liu   +7 more
semanticscholar   +1 more source

Tumor-on-a-chip devices for cancer immunotherapy

Engineering Technologies and Clinical Translation, 2022
This chapter introduces a range of microfluidics-based approaches to the manipulation of immune cells and the recapitulation of the tumor microenvironment, i.e., Tumor-on-a-Chip, for elucidating the mechanism of immune surveillance and for advancing ...
X. Mu, Y. S. Zhang
semanticscholar   +1 more source

Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells.

Lab on a Chip
Chimeric antigen receptor (CAR)-T cell immunotherapy, effective in blood cancers, shows limited success in solid tumors, such as prostate, pancreatic, and brain cancers due, in part, to an immunosuppressive tumor microenvironment (TME). Immunosuppression
Rajul S Bains, Tara G Raju, Layla C. Semaan, Anton V Block, Yukiko Yamaguchi, S. Priceman, Steven C. George, V. Shirure   +7 more
semanticscholar   +1 more source

Vascularized Tumor Spheroid-on-a-Chip Model Verifies Synergistic Vasoprotective and Chemotherapeutic Effects.

ACS Biomaterials Science & Engineering, 2022
Prolyl hydroxylases (PHD) inhibitors have been observed to improve drug distribution in mice tumors via blood vessel normalization, increasing the effectiveness of chemotherapy. These effects are yet to be demonstrated in human cell models.
Zhiwei Hu, Yuanxiong Cao, Edgar A. Galan, Liang Hao, Haoran Zhao, Jiyuan Tang, Gan Sang, Hanqi Wang, Bing Xu, Shaohua Ma   +9 more
semanticscholar   +1 more source

DLM-GelMA/tumor slice sandwich structured tumor on a chip for drug efficacy testing.

Lab on a Chip
The in vitro recapitulation of tumor microenvironment is of great interest to preclinical screening of drugs. Compared with culture of cell lines, tumor organ slices can better preserve the complex tumor architecture and phenotypic activity of native ...
Wenqi Hu, Ho-Pan Bei, Hong-Wei Jiang, Di Wu, Xiaorui Yu, Xintong Zhou, Qiuwan Sun, Qinrui Lu, Qijun Du, Liangwen Wang, Zhi Luo, Guo-Hua Wu, Xin Zhao, Shuqi Wang   +13 more
semanticscholar   +1 more source

Abstract 999: In vivo breast tumor stiffness and vascular drug delivery recapitulated in a microfluidic tumor-on-a-chip

Cancer Chemistry, 2019
Biomimetic tissue engineered microfluidic cancer models offer a higher degree of spatial, temporal and structural precision in controlling the physical parameters and component characteristics of the native tumor microenvironment (TME).
Benjamin Anbiah, Iman Hassani, Nicole L. Habbit, L. Jasper, D. Ramsay, B. Prabhakarpandian, R. Arnold, E. Lipke   +7 more
semanticscholar   +1 more source

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis.

Lab on a Chip, 2019
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly progressing from academic proof-of-concept studies to valid solutions to real-world problems.
Jihoon Ko, J. Ahn, Suryong Kim, Younggyun Lee, Jungseub Lee, Dohyun Park, N. Jeon   +6 more
semanticscholar   +1 more source

Organ-on-a-Chip Systems for Modeling Tumor and Normal Tissue Microenvironments in Radiotherapy Research

Trends in Biotechnology
Radiation therapy precisely targets tumors with ionizing radiation, aiming to achieve local control while minimizing collateral damage to surrounding healthy tissues. Radiation research is often carried out in animal models, but these suffer from ethical
R. Nasiri, A. Sankaranthi, G. Pratx
semanticscholar   +1 more source

Engineered Tumor-Immune Microenvironment On-a-Chip to Study T Cell - Macrophage Interaction in Breast Cancer Progression

Advanced Healthcare Materials
Evolving knowledge about the tumor–immune microenvironment (TIME) is driving innovation in designing novel therapies against hard‐to‐treat breast cancer.
Twinkle Jina Minette Manoharan, K. Ravi, Abhirami P. Suresh, A. Acharya, Mehdi Nikkhah   +4 more
semanticscholar   +1 more source

Electro Kinetic and Flow Analysis in Microfluidic Lab on a Chip for Brain Tumor Biomarkers

International Conference on Communication and Electronics Systems
Modern labs on a chip microfluidics system are highly suited to patient diagnostics at the precise point when they are inventive and accurate enough to assess medications for early identification.
P. Balaji, D. Devasena, K. Prashanthini, S. Kasthuri, A. Vennila, S. Suganya   +5 more
semanticscholar   +1 more source