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Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy
Nanotechnology, 2018Cancer has become the most prevalent cause of deaths, placing a huge economic and healthcare burden worldwide. Nanoparticles (NPs), as a key component of nanomedicine, provide alternative options for promoting the efficacy of cancer therapy. Current conventional cancer models have limitations in predicting the effects of various cancer treatments.
Yimin Wang +5 more
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High‐Throughput Tumor‐on‐a‐Chip Platform to Study Tumor–Stroma Interactions and Drug Pharmacokinetics [PDF]
Advanced Healthcare Materials, 2020 Chun-Wei Chi +2 more
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Channel-assembling tumor microenvironment on-chip for evaluating anticancer drug efficacy
Journal of Controlled ReleaseOrgan-on-a-chip is an advanced system for evaluating drug response in diseases. It simulates the in vivo tumor microenvironment, aiding in the understanding of drug mechanisms and tumor responses. It mimics the structure of the tumor microenvironment and the dynamic conditions within the body.
Hyo-Il Jung, Bongseop Kwak
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The Microenvironment of Solid Tumors: Components and Current Challenges of Tumor-on-a-Chip Models
Tissue Engineering Part B: ReviewsSolid tumors represent the most common type of cancer in humans and are classified into sarcomas, lymphomas, and carcinomas based on the originating cells. Among these, carcinomas, which arise from epithelial and glandular cells lining the body's tissues, are the most prevalent.
Ilva de Fátima, Souza +4 more
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Tumor organoid and tumor-on-a-chip equipped next generation precision medicine
BiofabricationAbstract Recently, significant advancements have been witnessed in various in vitro treatment evaluation models, especially organoids and organs-on-chips. In vitro culture of cancer cells and drug screening are key technical components in functional oncology precision medicine. However, most studies primarily focus on constructing models
Wentao Zhao +8 more
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Computational model of the cancer necrotic core formation in a tumor-on-a-chip device
Journal of Theoretical BiologyThe mechanisms underlying the formation of necrotic regions within avascular tumors are complex and poorly understood. In this paper, we investigate the formation of a necrotic core in a 3D tumor cell culture within a microfluidic device, considering oxygen, nutrients, and the microenvironment acidification by means of a computational-mathematical ...
Bonifácio, Elton Diêgo +6 more
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Immunocompetent tumor-on-a-chip: A translational tool for drug screening and cancer therapy
Critical Reviews in Oncology/HematologyTumor is one of the major diseases endangering human health while establishing an efficient in vitro tumor microenvironment (TME) model, which is an effective way to reveal the nature of the tumor and develop therapeutic methods. In recent years, due to the continuous development of lab-on-a-chip technology and tumor biology, various tumor-on-a-chip ...
Anqi Liang +6 more
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Tumor-on-a-chip devices for cancer immunotherapy
2022Xuan Mu, Yu Shrike Zhang
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The Investigation of Tumor-on-a-Chip via 3D-Bioprinting Methods
2021Die zweithäufigste Todesursache weltweit, nach Herz-Kreislauf-Erkrankungen, ist Krebs mit ständig steigender Prävalenz. Cholangiokarzinom ist ein vielfältiger, seltener und aggressiver epithelialer Tumor mit weltweit zunehmender Inzidenz und schlechter Prognose. Daher wird viel Augenmerk auf die Suche nach einem geeigneten Arzneimittel-Screening-Modell
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Advanced Therapeutics
AbstractVascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient responses to therapies ...
Pratibha Parihar +5 more
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AbstractVascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like those observed in tumors through microfluidic devices, which are meticulously designed to offer a faithful representation of cancer in vitro, exploration of tumor biology, evaluation of drug efficacy, and anticipation of patient responses to therapies ...
Pratibha Parihar +5 more
openaire +1 more source