Results 91 to 100 of about 8,258,963 (388)

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]

, 2018
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
Abdel-Aziz, Ahmadzadeh, Al-Zhoughbi, Albina, Alkan, Allard, Allen, Altman, Alves-Filho, Amelio, Araújo, Argilés, Arora, Arts, Aslanian, Astaldi, Attieh, Augsten, Auvinen, Babbar, Baker, Balasubramanian, Baltazar, Bauer, Bello-Fernandez, Beloribi-Djefaflia, Berchner-Pfannschmidt, Berge, Berrone, Birendra, Bloch-Frankenthal, Bock, Bock, Bonuccelli, Boros, Boudreau, Boukalova, Britten, Brooks, Broome, Bueno, Buqué, Burnet, Cadamuro, Cahlin, Cantelmo, Cao, Carito, Carmeliet, Carmeliet, Caro, Carrascosa, Casazza, Caspani, Catane, Cavalcante, Chakravarty, Chakravarty, Chakravarty, Chang, Chang, Chang, Chappell, Chaudhary, Chen, Chen, Chen, Chiarini, Chittezhath, Choi, Choi, Clark, Clem, Clem, Cohen, Colegio, Collins, Commisso, Covarrubias, Covarrubias, Dang, Dang, Das, Dasgupta, Daurkin, DeBerardinis, DeBerardinis, Delgoffe, Delgoffe, Dell’ Antone, Desai, DiNapoli, Dirat, Dobrina, Doherty, Dong, Draoui, Dufour, Eason, Eelen, El Sayed, Elia, Elwood, Eminel, Fallarino, Farabegoli, Farber, Feun, Fields, Figueras, Filipp, Fischer, Flaig, Flint, Floor, Floridi, Folkman, Folkman, Franklin, Gacche, Ganeshan, Garber, García-Caballero, García-Faroldi, García-Faroldi, Gatenby, Gazi, Geiger, Gentric, Gerner, Gershtein, Ghashghaeinia, Gonen, Goveia, Granchi, Grieninger, Grivennikov, Gross, Gunnink, Guo, Guo, Guppy, Guth, Halestrap, Han, Hanahan, Hanahan, Hanai, Harjes, Harjes, Haskell, Hatzivassiliou, Hayakawa, Hessini, Hitosugi, Ho, Ho, Hoff, Holm, Hosono, Huang, Hubler, Hui, Häusler, Hée, Ignatenko, Ioannesyants, Ip, Jiménez-Valerio, Jiménez-Valerio, Jochems, Johansen, Jones, Kabat, Kafkewitz, Kamphorst, Kamphorst, Kamphorst, Kannan, Karpel-Massler, Katt, Kawasaki, Kelly, Kim, Klimp, Ko, Koliaraki, Kouidhi, Koukourakis, Kridel, Krishna, Kroemer, Krützfeldt, Kubatka, Kucharzewska, la Cueva, Labow, Laing, Lampropoulou, Le, Lechowski, Lee, Lee, Leek, Leighton, Leopold, LePage, Lerma Barbaro, Li, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lopes-Coelho, Lu, Lucca, Lukey, Lunt, Luo, López-Lázaro, Löb, Ma, Madaan, Maity, Marchiq, Martinez-Outschoorn, Martinez-Outschoorn, Maráz, Mashima, Masri, Matusewicz, McCann, McKee, McLaughlin, Medina, Medina, Merchan, Meyer, Mider, Missiaen, Mitra, Mockler, Moreno-Sánchez, Morrison, Mu, Murray-Stewart, Márquez, Márquez, Nacev, Nancolas, Newsholme, Nieman, Nisoli, Noman, Norrby, Noy, Nurjhan, Nyberg, Ocaña, Ohmura, Oka, Opitz, Orimo, Pallangyo, Palm, Panda, Papandreou, Parra-Bonilla, Parry, Pascual, Pasquier, Patsoukis, Pavlides, Pavlova, Pelicano, Pellerin, Pennisi, Penny, Peters, Pisarsky, Pizer, Polanski, Polet, Pollard, Polyak, Possemato, Potente, Potente, Prager, Prager, Pushkina, Pérez-Escuredo, Quatromoni, Quesada, Quesada, Rabold, Ramjiawan, Rashid, Rattigan, Reihill, Reitzer, Ribatti, Ribatti, Ribeiro, Richard, Rider, Roberts, Rodríguez-González, Rodríguez-Prados, Rohle, Romero, Romero-García, Roy, Roy, Ruan, Ruiz-Pérez, Russell, Ryu, Saez, Salimian Rizi, Salimian Rizi, Samal, Samudio, Santos, Sanuphan, Sasaki, Saulnier Sholler, Scherz-Shouval, Schoors, Schulze, Segura, Sekar, Selak, Seltzer, Serafini, Shapot, Shapot, Shapot, Sharkia, Shime, Shin, Shurbaji, Sieber, Siu, Skelton, Song, Sonveaux, Sonveaux, Souba, Sousa, Spahr, Spinelli, Spolarics, Stacpoole, Stern, Stuart, Stumvoll, Su, Sukumar, Sánchez-López, Tachibana, Takigawa, Talekar, Tanese, Tang, Tannahill, Tebbe, Thomas, Thomas, Thornburg, Tisdale, Torosian, Torres, Trudeau, Ullah, Uray, Urdiales, Vander Heiden, Vander Heiden, Varricchi, Vasudevan, Velaei, Vera, Vornovitskaya, Végran, Wagner, Wakil, Wang, Wang, Wang, Wang, Warburg, Warburg, Wen, Whitaker-Menezes, Williams-Ashman, Wilson, Wood, Woodward, Woster, Wu, Wu, Xie, Yamanishi, Yang, Yang, Yau, Yen, Yoshida, Yoshizaki, Yu, Yuan, Yuan, Yuan, Yun, Zabala-Letona, Zahalka, Zhan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou, Zhu, Ziegler   +431 more
core   +2 more sources

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

Science, 2018
Mining immunotherapy clinical trials Clinical trial data can provide a wealth of information about how drugs work. Yet such information often belongs to pharmaceutical companies and is rarely accessible to the scientific community at large.
R. Cristescu, R. Mogg, M. Ayers, Andrew Albright, E. Murphy, J. Yearley, Xinwei Sher, Xiao Qiao Liu, Hongchao Lu, M. Nebozhyn, Chunsheng Zhang, J. Lunceford, A. Joe, Jonathan C Cheng, A. Webber, N. Ibrahim, E. Plimack, P. Ott, T. Seiwert, A. Ribas, T. Mcclanahan, J. Tomassini, A. Loboda, D. Kaufman   +23 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Residual Tumor Confers a 10-Fold Increased Risk of Regrowth in Clinically Nonfunctioning Pituitary Tumors. [PDF]

, 2019
ObjectiveWe evaluated tumor recurrence and regrowth rates following endoscopic transnasal transsphenoidal (TNTS) surgical removal in a consecutive series of clinically nonfunctioning pituitary adenomas (CNFTs).DesignRetrospective chart review of clinical,
Bergsneider, Marvin, Dabbagh, Asmaa, Heaney, Anthony P, Linetsky, Michael, Maletkovic, Jelena, Salamon, Noriko, Vinters, Harry V, Wang, Marilene B, Yong, William H, Zahid, Abdul, Zhang, Dongyun   +10 more
core   +1 more source

Angiogenic inflammation and formation of necrosis in the tumor microenvironment influence patient survival after radical surgery for de novo hepatocellular carcinoma in non-cirrhosis [PDF]

, 2019
BACKGROUND: Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system.
Atanasov, Georgi, Aust, Gabriela, Dietel, Corinna, Dino, Karoline, Hau, Hans-Michael, Pratschke, Johann, Schierle, Katrin, Schmelzle, Moritz, Seehofer, Daniel   +8 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]

, 2018
Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula, Meiss, Roberto P., Montagna, Daniela Romina, Ruggiero, Raul Alejandro   +3 more
core   +1 more source

Efficacy and safety of a 3D-printed arthrodesis prosthesis for reconstruction after resection of the proximal humerus: preliminary outcomes with a minimum 2-year follow-up

BMC Musculoskeletal Disorders, 2022
Background The purpose of this study was to investigate the feasibility of using a three-dimensional (3D)-printed arthrodesis prosthesis for reconstruction of the proximal humeral defect after tumor resection.
Haijie Liang, Wei Guo, Yi Yang, Dasen Li, Rongli Yang, Xiaodong Tang, Taiqiang Yan   +6 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model [PDF]

, 2011
Exosomes are endosome-derived small membrane vesicles that are secreted by most cell types including tumor cells. Tumor-derived exosomes usually contain tumor antigens and have been used as a source of tumor antigens to stimulate anti-tumor immune ...
A Clayton, A Clayton, A Clayton, A Clayton, AV Miagkov, C Liu, C Thery, C Thery, Chenjie Yang, D Pardoll, DD Taylor, DD Taylor, ER Lechman, ER Lechman, F Andre, F Chalmin, F Xiu, FM Marincola, G van Niel, H Navabi, H Peche, I Marigo, IS Zeelenberg, J Mallegol, J Wolfers, JD Whalen, Jean Kanellopoulos, JF Jacysyn, JL Hood, K Denzer, KL Rock, LD Falo Jr, M Karlsson, M Szajnik, MC Fantini, MW Moore, N Prado, Nicole R. Bianco, Paul D. Robbins, R Meade, R Valenti, RA Seder, RE Cone, S Dai, S Dai, S Dai, S Keller, S Ostman, S Yu, SC Ghivizzani, Seon-Hee Kim, SH Kim, SH Kim, SH Kim, SH Kim, SH Kim, TJ D'Orazio, U Sack, W Chen, W Zou, Y Yang, Y Zhang   +61 more
core   +5 more sources