Results 101 to 110 of about 3,691,927 (315)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Chinese expert consensus on the diagnosis and treatment of leptomeningeal metastasis from breast cancer

Zhongguo aizheng zazhi
Leptomeningeal metastasis from breast cancer is one of the severe complications of advanced breast cancer, characterized by complex and variable clinical manifestations, rapid disease progression, and an extremely poor prognosis.
Chinese Medical Education Association Tumor Drug Clinical Research Professional Committee, Shanghai Anti-Cancer Association Tumor Drug Clinical Research Professional Committee, Yangtze Academic Breast Alliance   +2 more
doaj  

Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes

Scientific Reports
Mitotic catastrophe (MC) is a novel form of cell death that plays an important role in the treatment and drug resistance of colon adenocarcinoma (COAD). However, MC related genes in COAD treatment and prognosis evaluation are rarely studied.
Yinglei Liu, Yamin Zhao, Siming Zhang, Shen Rong, Songnian He, Liqi Hua, Xingdan Wang, Hongjian Chen   +7 more
doaj   +1 more source

Newsletter: A Report to the Physicians of Texas

, 1979
Quarterly newsletter from the University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute discussing cancer care and research to inform physicians of recent developments in the ...
McBurney, Marcia K., M.D. Anderson Hospital and Tumor Institute   +1 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Tumor-associated macrophages contribute to tumor hypoxia and glycolysis

, 2017
1
Bok, Seoyeon, AHN, G ONE, 김영은, BUMJOO, HONG, HOI, BIN JEONG   +4 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Author Correction: Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

Scientific Reports, 2021
Gautier Follain, Naël Osmani, Valentin Gensbittel, Nandini Asokan, Annabel Larnicol, Luc Mercier, Maria Jesus Garcia‑Leon, Ignacio Busnelli, Angelique Pichot, Nicodème Paul, Raphaël Carapito, Seiamak Bahram, Olivier Lefebvre, Jacky G. Goetz   +13 more
doaj   +1 more source

Association between serum levels of 12 different cytokines and short-term efficacy of chemoradiotherapy in esophageal squamous cell carcinoma

Discover Oncology
Background Esophageal squamous cell carcinoma (ESCC) has a poor prognosis, with chemoradiotherapy (CRT) being a key treatment method. This study focused on circulating cytokines as potential predictors of treatment response and prognosis in patients with
Yaping Zhang, Qiufeng Qi, Ming Zhu, Yun Peng, Yanqing Bao, Jun Liu, Yanzhi Bi, Min Xiao, Shaohua Chi, Yongping Liu   +9 more
doaj   +1 more source