Results 81 to 90 of about 2,831,620 (267)
Fighting tumors with tumors [PDF]
Science-Business eXchange, 2011 Researchers at The Rogosin Institute have used cancer cell–containing agarose beads to inhibit tumor proliferation in animals. The beads already are in an investigator-sponsored Phase II trial in patients with pancreatic cancer, advanced colorectal cancer or refractory prostate cancer.
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Frontiers in Public HealthObjectiveTo investigate the knowledge, attitudes, and practices (KAP) concerning osteoporosis among hormone receptor-positive (HR+) breast cancer patients.MethodsA cross-sectional study was conducted from November, 2023, to March, 2024 among HR+ breast ...
Xiaoyan Chen +8 more
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Der Radiologe, 2007 Magnetic resonance imaging is a routine diagnostic measure for a suspected intracerebral mass. Computed tomography is usually also indicated. Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location.
Grunwald, I +4 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
World Journal of Surgical OncologyObjective To evaluate the potential of RASSF1A and SHOX2 methylation status in intraoperative pleural lavage (IPL) fluid for assessing invasiveness and predicting postoperative recurrence in non-small cell lung cancer (NSCLC).
Jianbin Hou +10 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
World Journal of Surgical OncologyAims This study aims to evaluate the impact of four SNPs of interleukin-10 (IL- 10) gene, and the interaction with the environmental factors on the risk of esophageal cancer (EC) based on a Chinese Han population. Methods Hardy-Weinberg equilibrium (HWE)
Jiamin Zhu +5 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
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