Results 121 to 130 of about 3,691,927 (315)

Knowledge, attitudes, and practices regarding osteoporosis among hormone receptor-positive breast cancer patients: a cross-sectional study

Frontiers in Public Health
ObjectiveTo investigate the knowledge, attitudes, and practices (KAP) concerning osteoporosis among hormone receptor-positive (HR+) breast cancer patients.MethodsA cross-sectional study was conducted from November, 2023, to March, 2024 among HR+ breast ...
Xiaoyan Chen, Rongfang Xu, Xiangyang Sun, Xianghua Huang, Lingli Chen, Jibing Liu, Xinghui Li, Lulu Pan, Ying Cheng   +8 more
doaj   +1 more source

Quantitation of rare circulating tumor cells by folate receptor alpha ligand-targeted PCR in bladder transitional cell carcinoma and its potential diagnostic significance

, 2014
Numerous attempts for detection of circulating tumor cells (CTC) have been made to develop reliable assays for early diagnosis of cancers. In this study, we validated the application of folate receptor alpha (FR alpha) as the tumor marker to detect CTC ...
Li, Feiyang, Cai, Zhiming, Zhou, Fangjian, Zhao, Rongchang, Zou, Xiangjun, Xia, Ye, Zhang, Lei, Qi, Fuming, Liu, Chunxiao, Sun, Xiaojuan, Xing, Li, Liu, Yuchen, Gui, Yaoting, Wang, Xuliang, Wang, Yongqiang, Tang, Junlong, Lu, Jingxiao, Li, Jiaqiang, Zou, Xiaowen, Li, Cailing   +19 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Correlation analysis on interaction between Interleukin 10 gene and smoking with esophageal cancer risk in a Chinese Han population

World Journal of Surgical Oncology
Aims This study aims to evaluate the impact of four SNPs of interleukin-10 (IL- 10) gene, and the interaction with the environmental factors on the risk of esophageal cancer (EC) based on a Chinese Han population. Methods Hardy-Weinberg equilibrium (HWE)
Jiamin Zhu, Baixia Yang, Feng Ni, Cheng Tan, Yun Guan, Xiaogang Zhai   +5 more
doaj   +1 more source

Salmonella Breaks Tumor Immune Tolerance by Downregulating Tumor Programmed Death-Ligand 1 Expression

, 2019
Immunotherapy is becoming a popular treatment modality in combat against cancer, one of the world’s leading health problems. While tumor cells influence host immunity via expressing immune inhibitory signaling proteins, some bacteria possess ...
Che-Hsin Lee, Man-Chin Chen, Christian Ronquillo Pangilinan   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

[Supratentorial tumors].

Der Radiologe, 2007
Magnetic resonance imaging is a routine diagnostic measure for a suspected intracerebral mass. Computed tomography is usually also indicated. Further diagnostic procedures as well as the interpretation of the findings vary depending on the tumor location.
Grunwald, I, Dillmann, K, Roth, C, Backens, M, Reith, W   +4 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Trypsin digest of cancer cells surface stimulates anti-tumor immune response better than cancer cells themselves

, 2010
Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development.
Balashova Elena, Petr Lokhov
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source