Results 191 to 200 of about 2,684,188 (268)

Context-Dependent Dual Roles of the Plexin-B Family in Cancer Progression: Mechanisms and Therapeutic Implications. [PDF]

Cancer Manag Res
Mao X, Lin W, Zhang X, Yang M, Shen J, Liang H, Song J, Meng L, Long F, Wang T, Li Y.   +10 more
europepmc   +1 more source

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

A characterisation of the immune cells in immunocompetent and immunodeficient mice with orthotopic brain tumors. [PDF]

Clin Transl Immunology
Gardam B, Nam E, Kollis PM, Kilyen-Coles J, Lenin S, Gliddon BL, Tea MN, Pitson SM, Brown MP, Ebert LM, Gargett T.   +10 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Modeling tumor transport and growth with poroelastic biopolymer networks.

Soft Matter
Li Z, Ren Y, Kemkar S, Mollenkopf P, Kochanowski J, Janmey PA, Purohit PK, Radhakrishnan R, Vining KH.   +8 more
europepmc   +1 more source

Engineering Extracellular Vesicles for Tumor Targeted Therapy: Source Optimization, Modification, and Clinical Application. [PDF]

Int J Nanomedicine
Sui J, Qin H, Zhang Z, Lv X, Lin X, Liu Z, Zhao X, Liu X, Zhang H.   +8 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Giant cauda equina neuroendocrine tumor with superficial siderosis: illustrative case. [PDF]

J Neurosurg Case Lessons
Lin Y, Abe K, Hiu T, Kurohama H, Tsunoda K, Yoshida K, Uotani S, Koike H, Takeuchi M, Shirahama M, Matsuo A, Uchida D, Matsunaga Y, Baba S, Ujifuku K, Nakashima M, Matsuo T.   +16 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source