Results 201 to 210 of about 2,743,175 (268)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Zinc-Doped Calcium Phosphate Nanoagonists Amplifies cGAS-STING Signaling for Boosting Pyroptosis-Induced Cancer Immunotherapy. [PDF]

J Funct Biomater
Yang B, Li X, Zhang M, Guo S, Wang X, Chen P, Yu D, Qi C, Cai K.   +8 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy. [PDF]

J Transl Med
Ducoin K, Beauvais T, Goward J, Ahondo M, Lambot S, Mordelet A, Daminette A, Thabot M, Deng J, Tian S, Rulli S, Quereux G, Khammari A, Labarrière N.   +13 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Endothelial AGO1 deficiency reduces breast cancer burden in mice. [PDF]

Angiogenesis
Liu X, Tapia A, Yuan D, Tang X, Luo Y, Malhi NK, Chen M, Law KH, Haidar M, Giacobetti S, Sun J, Park A, Priceman SJ, Chen ZB.   +13 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Prognostic Risk Model Based on Immune Genes in Thyroid Cancer and Its Correlation With Tumor-Associated Immune Cell Infiltration Abundance. [PDF]

Cancer Med
Zhang Y, Song S, Yu X, Li J.
europepmc   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas Showing Spontaneous Regression Followed by Regrowth: A Case Report. [PDF]

Surg Case Rep
Ikeda Y, Hashimoto D, Yamaki S, Matsumura K, Ishida H, Mii S, Miyazaki H, Matsui Y, Nguyen ST, Satoi S.   +9 more
europepmc   +1 more source

Irreversible Electroporation Enhances Solid Tumor Infiltration and Selective Cancer Cell Lysis by CAR T Cells. [PDF]

Clin Cancer Res
Vista WR, Malik V, Sheehan MC, Ismail J, Hocine HR, Ganbaatar U, Misawa K, Guzman Valle J, Banerjee S, Solomon SB, Adusumilli PS, Srimathveeravalli G.   +11 more
europepmc   +1 more source