The architecture of co-culture spheroids regulates tumor invasion within a 3D extracellular matrix [PDF]
arXiv, 2020 Tumor invasion, the process by which tumor cells break away from their primary tumor and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D tumor invasion assays consisted of single tumor cells embedded within an extracellular matrix (ECM). These assays taught us much of what we know today on how key biophysical
arxiv
Prognostic significance of primary-tumor extension, stage and grade of nuclear differentiation in patients with renal cell carcinoma [PDF]
, 2002 Surgery remains the preferred therapy for renal cell carcinoma. The various adjunctive or complementary therapies currently yield disappointing results. Identifying reliable prognostic factors could help in selecting patients most likely to benefit from ...
Barbarosos A +7 more
core
Enhancement of experimental metastasis by tumor necrosis factor [PDF]
, 1993 The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model.
Echtenacher, Bernd +5 more
core +2 more sources
World Journal of Surgical Oncology, 2022 Background Gastric cancer (GC) is the sixth most common cancer. China is one of the most frequent GC occurred countries, and Wuwei, Gansu, is one of the highest incidence area in China.
Ping Fan +6 more
doaj +1 more source
Rigorous results of limiting behaviors of total tumor size under cyclic intermittent therapy for the system of reversible phenotype-switchable tumor cells [PDF]
arXiv, 2023 We are keenly interested in finding the limiting behaviors of total tumor size when tumor cells are subject to the periodic repetition of therapy and rest periods, called intermittent cyclic therapy. We hypothesize that each tumor cell can take either therapy-sensitive or therapy-tolerant phenotype, its phenotype transition is mainly driven by the ...
arxiv
Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy [PDF]
, 2017 Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis.
A C Belkina +7 more
core +1 more source
DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs [PDF]
, 2019 Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with ...
Barcus, Craig E +9 more
core +1 more source
Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions [PDF]
, 2010 The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce ...
Gong, Jianlin +10 more
core +4 more sources
Frontiers in Bioengineering and Biotechnology, 2022 One of the most effective treatments for diabetes is to design a glucose-regulated insulin (INS) delivery system that could adjust the INS release time and rate to reduce diabetes-related complications.
Yanguang Yang +5 more
doaj +1 more source
The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]
, 2019 Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel +4 more
core +1 more source