Results 51 to 60 of about 235,837 (357)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

Microwave Ablation of Small Hepatic Metastases Using MR Guidance and Monitoring: Clinical Safety and Efficacy

open access: yesCancer Management and Research, 2021
Zhaonan Li,* Dechao Jiao,* Chaoyan Wang, Jing Li, Zaoqu Liu, Wenguang Zhang, Xinwei Han Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, People’s Republic of China*These authors ...
Li Z   +6 more
doaj  

New progress in tumor treatment based on nanoparticles combined with irreversible electroporation

open access: yesNano Select, 2022
Nanoknife is a new tumor ablation technology. It forms nano permanent perforation on tumor cells by releasing high‐voltage pulses, destroying the intracellular balance and making cells apoptosis rapidly.
Lei Xu   +4 more
doaj   +1 more source

Radiofrequency ablation for liver tumors abutting complex blood vessel structures: treatment protocol optimization using response surface method and computer modeling

open access: yesInternational Journal of Hyperthermia, 2022
Objective To achieve a result of a large tumor ablation volume with minimal thermal damage to the surrounding blood vessels by designing a few clinically-adjustable operating parameters in radiofrequency ablation (RFA) for liver tumors abutting complex ...
Zheng Fang   +6 more
doaj   +1 more source

Microwave ablation therapy for colorectal liver metastases [PDF]

open access: yes, 2016
BACKGROUND: The gold standard treatment for colorectal cancer liver metastases (CRCLM) is surgical resection. Unfortunately, the majority of patients with colorectal hepatic metastases are not candidates for resection.
Price, Jacqueline
core   +1 more source

Percutaneous Ablation of Hepatic Tumors [PDF]

open access: yesSeminars in Interventional Radiology, 2010
The liver is a common site of both primary and secondary malignancy resulting in significant morbidity and mortality. Careful patient evaluation and triage allows for optimal utilization of all oncologic therapies, including radiation, systemic chemotherapy, surgery, transarterial therapies, and ablation. Although the role of interventional oncologists
James R, McCarley, Michael C, Soulen
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Safety margin assessment after microwave ablation of liver tumors: inter- and intrareader variability

open access: yesRadiology and Oncology, 2020
The aim of the study was to evaluate the inter- and intrareader variability of the safety margin assessment after microwave ablation of liver tumors using post-procedure computed tomography (CT) images as well as to determine the sensitivity and ...
Schaible Jan   +6 more
doaj   +1 more source

T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. [PDF]

open access: yes, 2016
BackgroundCurrent clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the ...
Bucknor, Matthew   +4 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

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