Results 101 to 110 of about 68,638 (278)

RAS, Cellular Plasticity, and Tumor Budding in Colorectal Cancer [PDF]

Frontiers in Oncology, 2019
The high morbidity and mortality of colorectal cancer (CRC) remain a worldwide challenge, despite the advances in prevention, diagnosis, and treatment. RAS alterations have a central role in the pathogenesis of CRC universally recognized both in the canonical mutation-based classification and in the recent transcriptome-based classification.
Maffeis, Valeria, Nicolè, Lorenzo, Cappellesso, Rocco   +2 more
openaire   +3 more sources

A cell-based assay for CD63-containing extracellular vesicles [PDF]

, 2019
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are few.
Cashikar, Anil G, Hanson, Phyllis I
core   +2 more sources

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Comprehensive single-cell transcriptome landscape of metastatic colorectal cancer identifies budding-potential cells and their interactions with cancer-associated fibroblasts

npj Precision Oncology
Tumor budding is positively associated with colorectal cancer (CRC) metastasis. In this study, we integrated a single-cell transcriptomic dataset of 287 CRC samples to comprehensively illustrate the transcriptomic landscape of metastatic CRC and ...
Yao Ma, Lijian Wang, Ziyue Zhang, Yifei Zhao, Zimin Zhao, Renjie Luo, Junwei Wang, Limei Guo, Wei Fu, Kai Miao, Xin Zhou   +10 more
doaj   +1 more source

Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]

, 2018
In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira, Carollo, Maria, Fabbri, Alessia, Falchi, Mario, Fecchi, Katia, Fiani, Maria Luisa, Gallina, Angelo, Palermo, Angela, Parisi, Sofia, Pasquini, Luca, Sargiacomo, Massimo, Zanetti, Cristiana   +11 more
core   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Analyzing Tumor Budding Scores in Invasive Breast Carcinoma: A Tertiary Care Center Study in South India

Journal of Pharmacy and Bioallied Sciences
Introduction and AimTumor budding is a distinctive phenomenon which involves the presence of small clusters or individual cancer cells at the invasive front of tumors.
Vasudevan Sudha, Kannan Kavitha, Raghavan ATM Venkat, Sulochana Sonti   +3 more
doaj   +1 more source

Characterising the tumour morphological response to therapeutic intervention:an ex vivo model [PDF]

, 2012
In cancer, morphological assessment of histological tissue samples is a fundamental part of both diagnosis and prognosis. Image analysis offers opportunities to support that assessment through quantitative metrics of morphology.
Bown, James L., Eberst, Alistair, Falconer, Ruth E., Harrison, David J., Houston, Alasdair N., Katz, Elad, Savage, Anne   +6 more
core   +5 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report.

PLoS ONE, 2020
BackgroundThe majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of ...
Inger-Heidi Bjerkli, Helene Laurvik, Elisabeth Sivy Nginamau, Tine M Søland, Daniela Costea, Håkon Hov, Lars Uhlin-Hansen, Elin Hadler-Olsen, Sonja E Steigen   +8 more
doaj   +1 more source