Results 141 to 150 of about 68,638 (278)

Reply to Comment on: “Impact of Depth of Invasion in Node‐Negative Oral Tongue Cancer Treated With Surgery Alone”

The Kaohsiung Journal of Medical Sciences, EarlyView.
Ming‐Hsien Tsai, Hui‐Ching Chuang, Chih‐Yen Chien   +2 more
wiley   +1 more source

Development and validation of a multimodal model based on histopathological and computed tomography imaging for predicting survival outcomes in stage III colorectal cancer

VIEW, EarlyView.
Patients with stage III colorectal cancer exhibit substantial heterogeneity in clinical outcomes despite receiving standardized treatments, which complicates accurate risk stratification. In this study, we integrated features derived from routine histopathological slides and preoperative computed tomography scans using machine learning to develop a ...
Danyi Li, Zhangxin Zhao, Genxia Wei, Weihao Qiu, Zhihao Lin, Jiankun He, Bingbing Li, Jing Wang, Lisheng Zheng, Feiyan Feng, Xiangkun Wu, Zhengyu Zhang, Jinbang Li, Mingxing Qiu, Shujing Guo, Chenglong Zhao, Ying Tan, Yueping Liu, Qingling Zhang, Yu Zhang, Li Liang   +20 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The septin cytoskeleton facilitates membrane retraction during motility and blebbing. [PDF]

, 2012
Increasing evidence supports a critical role for the septin cytoskeleton at the plasma membrane during physiological processes including motility, formation of dendritic spines or cilia, and phagocytosis.
Chen, Yi-Chun M, Gilden, Julia K, Krummel, Matthew F, Peck, Sebastian   +3 more
core  

Graph Neural Network‐Based Multi‐Scale Whole Slide Image Fusion for pT Staging of Muscle‐Invasive Bladder Cancer

Cancer Science, EarlyView.
Accurate pT staging in muscle‐invasive bladder cancer is essential for treatment and prognosis, but current methods rely on time‐consuming and variable microscopic evaluation. We developed a graph neural network–based model that integrates multi‐scale whole‐slide images to automate pT staging, achieving excellent performance with an AUC of 0.911 and ...
Qian Li, Qing Feng Chen, Nan Qing Liao
wiley   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, EarlyView.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]

, 2019
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra, Kõivomägi, Mardo, Rubin, Seth M, Sage, Julien, Skotheim, Jan M, Tambo, Carrie S, Topacio, Benjamin R, Xie, Shicong, Zatulovskiy, Evgeny   +8 more
core  

Skin lesion triage in organ transplant recipients using line‐field confocal optical coherence tomography: a retrospective classification study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background/objectives: Organ transplant recipients (OTRs) face an elevated risk of keratinocyte carcinomas (KC), leading to a lower threshold for biopsy. Line‐field confocal optical coherence tomography (LC‐OCT) is a non‐invasive imaging technique capable of visualizing malignant skin changes, yet its role in the management of OTRs remains ...
Kevin Jacobsen, Vinzent Kevin Ortner, Stine Regin Wiegell, Peter Alshede Philipsen, Merete Haedersdal   +4 more
wiley   +1 more source

Clinicopathological features of colon cancer depending on the dMMR status of the tumor

Бюллетень сибирской медицины
Aim. To conduct a clinical and morphological assessment of the characteristics of colon cancer depending on the dMMR / pMMR status of the tumor.Materials and methods.
S. S. Naumov, N. V. Krakhmal, M. N. Tarasov, M. I. Taranenko, E. V. Udut, Yu. V. Kolobovnikova, S. V. Vtorushin   +6 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source