Results 141 to 150 of about 1,252,032 (285)

Distance-based evaluation of tumor budding in colorectal cancer

Virchows Archiv
Abstract Tumor budding is an established adverse prognostic factor in colorectal cancer (CRC), based on the number of isolated single tumor cells or small tumor cell clusters at the invasive front. While bud counts are well studied, the prognostic significance of the spatial distribution and distance of tumor buds away from the tumor ...
Ville K. Äijälä, Päivi Sirniö, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Hanna Elomaa, Maarit Ahtiainen, Vesa-Matti Pohjanen, Taneli T. Mattila, Outi Lindgren, Olli Helminen, Erkki-Ville Wirta, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Toni T. Seppälä, Jan Böhm, Jukka-Pekka Mecklin, Anne Tuomisto, Markus J. Mäkinen, Juha P. Väyrynen   +21 more
openaire   +4 more sources

Experiences of Women and Clinicians During the Introduction of Uterine Transplantation to the UK: A Qualitative Case Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To explore the experiences of women and clinicians during the introduction of uterine transplantation (UTx) to the UK. Design A qualitative study utilising prospective case study methodology (interviews and observations) over 6 years.
Daisy Elliott, Richard J. Smith, Maeve Coyle, Rhiannon Macefield, Saliha Vali, Anni King, Natalie Blencowe, Cynthia Ochieng, Christin Hoffmann, Isabel Quiroga, Ben P. Jones, Ariadne L'Heveder, Kerry N. L. Avery, Jane M. Blazeby   +13 more
wiley   +1 more source

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Tumor Budding, Desmoplasia, and Lymphocytic Infiltration as Predictors of Aggressiveness in Invasive Breast Carcinoma of No Special Type

Journal of Nature and Science of Medicine
Background: Invasive breast carcinoma of no special type (IBC-NST) constitutes the predominant subtype of breast cancer. While conventional histopathological parameters guide prognostic assessment, increasing evidence underscores the relevance of tumor ...
Maureen Mushtaq, Anuja Sharma, K. C. Goswami   +2 more
doaj   +1 more source

Tumor budding score based on 10 high-power fields is a promising basis for a standardized prognostic scoring system in stage II colorectal cancer

, 2012
Tumor budding is recognized by the World Health Organization as an additional prognostic factor in colorectal cancer but remains unreported in diagnostic work due to the absence of a standardized scoring method.
Karamitopoulou, Eva, Lugli, Alessandro, Koelzer, Viktor H, Zlobec, Inti, Terracciano, Luigi, Horcic, Milo, Puppa, Giacomo   +6 more
core   +1 more source

Selective excitatory effects of γ‐glutamyl‐glycine, a glutathione metabolite, on GluN1 NMDA and mGlu5 receptors impacting synaptic plasticity

British Journal of Pharmacology, EarlyView.
Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu, Victoria Gizzi, Ugo Pasco, Fatiha Sebih, Yattou Zitouni, Pablo Jimenez, Valérie Rolland, Alain Chavanieu, Sébastien Estaran, Matthieu Rousset, Thierry Cens, Guillaume Cazals, Pierre Charnet, Janique Guiramand, Catherine Cohen‐Solal, Claudine Ménard, Marie‐Céleste de Jésus Ferreira, Nathalie Chevallier, Sonia Cantel, Michel Vignes, Julien Roussel   +20 more
wiley   +1 more source

The role of influenza neuraminidase transmembrane domain on budding and virus morphology [PDF]

, 2014
Influenza A virus neuraminidase (NA), a type II transmembrane glycoprotein plays a role in the cleavage of sialic acids and facilitating the release of mature virions from the surface of infected cells. NA has also previously been shown to play a role in
Roddy, Scott, Edward
core  

Biopsy of Iris and Anterior Chamber Tumours: Fine Needle, Minimally Invasive and Excision Techniques ‐ Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Several benign, inflammatory and malignant lesions can present as iris or anterior chamber masses, including iris naevi, cysts, adenomas, leiomyomas, nodules, vascular tumours, melanomas, metastases, as well as iris and pigment epithelium adenocarcinomas. Fortunately, benign iris lesions are much more common than malignant tumours and many can
Charles N. J. McGhee, Joevy Z. Lim, Peter W. Hadden, Jie Zhang   +3 more
wiley   +1 more source

GATA3 Expression in Breast Carcinoma: Associations with Clinicopathological Features

Indonesian Journal of Cancer
Background: Breast carcinoma is a heterogeneous disease, morphologically and molecularly. GATA binding protein 3 (GATA3) is an important marker in breast cancer origin. GATA3 expression and its prognostic value in breast carcinoma are inconsistent. Tumor
Ni Putu Sriwidyani, I Gusti Ayu Sri Mahendra Dewi, Naomi Juliana Sinaga, Ni Putu Wulan Tantri Dewi   +3 more
doaj   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source