Results 141 to 150 of about 834,324 (256)

Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer. [PDF]

Cell Death Dis
Kudo K, Greer YE, Crooks DR, Yang Y, Brender JR, Yoshida T, Harrington BS, Kamdar R, Korrapati S, Shibuya Y, Henegar L, Kopp J, Fujii T, Lipkowitz S, Annunziata CM.   +14 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Photodynamic therapeutic activity of novel porphyrins against lung squamous cell carcinoma. [PDF]

BMC Cancer
Meng H, Ding RQ, Jia L, Chen XP, Hu YH, Wang SM, Lv SQ, Feng F.   +7 more
europepmc   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

Advanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang, Lijuan Zhang, Jiaorong Tan, Fei Li, Yishan Jin, Limei He, Xin Yang   +6 more
wiley   +1 more source

Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model. [PDF]

Oncoimmunology
Pinto C, Widawski J, Zahalka S, Thaler B, Schuster LC, Lukowski SW, Ramírez F, Tirapu I.   +7 more
europepmc   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity. [PDF]

PLoS One
Kurtz KG, Lebedeva I, Pierre SA, Andrew D, Liao YR, Ambriz D, Vergnolle O, Shen L, Nyakatura E, Baca M, Scheinberg DA.   +10 more
europepmc   +1 more source

Phenotypic and functional differences of dendritic cells generated under different in vitro conditions [PDF]

, 2003
Ali, SA, Li, G, McArdle, SE, Mian, S, Rees, RC   +4 more
core   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment. [PDF]

J Immunother Cancer
Badillo-Godinez O, Niemi J, Helfridsson L, Karimi S, Ramachandran M, Mangukiya HB, Nelander S, Hellström M.   +7 more
europepmc   +1 more source