Results 171 to 180 of about 852,943 (301)

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Ginseng-Derived Exosomes Attenuate Immune Evasion in NSCLC via PD-L1 Modulation. [PDF]

Cancer Manag Res
Zhu LJ, Chen XQ, Lin QY, Feng JN, Yuan SF.   +4 more
europepmc   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Phenotypic and functional differences of dendritic cells generated under different in vitro conditions [PDF]

, 2003
Ali, SA, Li, G, McArdle, SE, Mian, S, Rees, RC   +4 more
core   +1 more source

Adaptive 3D Self-Assembly of Colorectal Cancer Cells With Unchanged Tumor Phenotype and Drug Sensitivity. [PDF]

Cancer Med
Zhang Y, Liu Y, Yang Y, Li Y, Liu L, Huang Y, Zhao W, Liu Y, Zhang M, Zhao Y, Li C.   +10 more
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

Targeting PGE2 mediated senescent neuron improves tumor therapy. [PDF]

Neuro Oncol
Zhao J, Wu L, Cai G, Ou D, Liao K, Yang J, Zhou L, Huang R, Lin S, Huang X, Lv Q, Chen J, Cao L, Chen J, Lin Y.   +14 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

In Vitro Analysis of PMEPA1 Upregulation in Mesenchymal Stem Cells Induced by Prostate Cancer Cells. [PDF]

Int J Mol Sci
Rakhmatullina AR, Zolotykh MA, Filina YV, Sagdeeva AR, Rozhina EV, Gabdoulkhakova AG, Boulygina EA, Miftakhova RR.   +7 more
europepmc   +1 more source

Binding of Vitamin E in Mammalian Tumor Cells in Culture

Experimental Biology and Medicine, 1981
Prasad, K N, Gaudreau, D, Brown, J
openaire   +3 more sources