Results 201 to 210 of about 913,938 (308)

Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis. [PDF]

Cell Death Dis
Xu M, He B, Zhou X, Shu L, Ma D.
europepmc   +1 more source

Multi‐Responsive Dendrimer‐Hyaluronic Acid Hydrogel With Lubricating and Immunoregulatory Functions for Synergistic Osteoarthritis Therapy

Advanced Functional Materials, EarlyView.
A hydrogel with dynamic cross‐links was formed by cross‐linking hyaluronic acid with curcumin‐preloaded, phenylboronic acid‐modified poly(amidoamine) dendrimers. This hydrogel exhibited excellent injectability and self‐healing ability, enabling controlled Cur release in response to low pH, high reactive oxygen species (ROS) generation, or mechanical ...
Junjie Liu, Mengsi Zhan, Haoyu Huang, Jianhong Wang, Cheng Ni, Xiaojun Zhou, Hannah Küttner, Cong Song, Xiangyang Shi, Andrij Pich   +9 more
wiley   +1 more source

Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors. [PDF]

Cancer Biol Med
Liu M, Chen Q, Zhang L, Zhou Y, Wen N, Jin J, Cai J, Su S, Li J, Zhao Q.   +9 more
europepmc   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Dissociable perfusion chip (DPC): perfusable microfluidic chip for single-cell screening of anti-cancer drugs in live glioblastoma explants.

Lab Chip
Kennedy DG, Zhao W, Chern TL, Yang M, Acosta N, Arumugam S, Upadhyayula P, Furnari J, Dovas A, Bruce JN, Canoll P, Sia SK, Sims PA.   +12 more
europepmc   +1 more source

Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia. [PDF]

iScience
Giorgetta S, Cortopassi F, Chanis T, Ni J, Correia MP, Sticht C, Ast V, Platten M, Cerwenka A, Stojanovic A.   +9 more
europepmc   +1 more source

Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity

Advanced Functional Materials, EarlyView.
Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen, Zheyuan Miao, Gary Tom, Austin H. Cheng, Elizaveta Gusarova, Benjamen Zondag, Tianyi Wu, Dianoosh Kalhori, Boris Hinz, Milad Abolhasani, Alán Aspuru‐Guzik, Eugenia Kumacheva   +11 more
wiley   +1 more source

Extracellular vesicles from canine mammary tumor cells promote macrophage M2 polarization and enhance tumor progression. [PDF]

Vet Res Commun
Chi NK, Kim SH, Lim GH, Song KH, An JH, Ryu MO, Seo KW.   +6 more
europepmc   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source