Results 121 to 130 of about 14,776,627 (313)
Hydrogen peroxide – production, fate and role in redox signaling of tumor cells
Cell Communication and Signaling, 2015 Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sensitive cysteine residues in enzymes and ...
Claudia Lennicke +4 more
semanticscholar +1 more source
Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. [PDF]
, 2014 The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages.
Albelda, Steven M. +13 more
core +2 more sources
Oncolytic Viruses—Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer
Frontiers in Oncology, 2017 Oncolytic viruses (OVs) are an emerging treatment option for many cancer types and have recently been the focus of extensive research aiming to develop their therapeutic potential.
Anwen Howells +5 more
doaj +1 more source
Colored Correlated Noises in Growth Model of Tumor [PDF]
arXiv, 2014 Stochastic resonance induced by external factor is considering to investigate the complex dynamics of tumor. The surrounding environment and the treatment effects on the tumor growth are considered as additive and multiplicative noises in growth model. The adaptability of tumor to treatment is presented by correlation of these two noises.
arxiv
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
Journal of Clinical Investigation, 2008 Tumors contain oxygenated and hypoxic regions, so the tumor cell population is heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production and release lactic acid, creating a lactate gradient that mirrors the oxygen gradient
P. Sonveaux +14 more
semanticscholar +1 more source
Multiplex detection of ten ESR1 mutations and AKT1 E17K in breast cancer using digital PCR
The Journal of Liquid BiopsyIntroduction: ESR1 mutations are now established as a key mechanism of resistance to endocrine therapy in estrogen-receptor–positive breast cancer (ER+ breast cancer) and their sensitive and specific detection in plasma-cell free DNA (plasma-cfDNA) is ...
Stavroula Smilkou +4 more
doaj
CellsCXCR4, JUNB and PD-L1 are implicated in cancer progression and metastasis. The current study investigated these biomarkers in CTCs isolated from metastatic prostate cancer (mPCa) patients at the RNA and protein levels.
Argyro Roumeliotou +15 more
doaj +1 more source
Cytotoxic activity of anti-DNA slgA-antibodies from milk of healthy women
Біологічні студії, 2011 Earlier we have shown that immunoglobulin preparations derived from milk of healthy women by precipitation with 50% ammonium sulfate, possess toxic activity toward several transformed and tumor cells in vitro (Kit Y., and others, Biotechnology 2008).
M. O. Starykovych +2 more
doaj +1 more source
Molecular CancerMetastatic breast cancer remains largely incurable, partly due to our incomplete understanding of its intricate underlying mechanisms. Notably, intercellular communication mediated by small extracellular vesicles and particles (sEVPs) has emerged as a ...
Tasneem Cheytan +17 more
doaj +1 more source