Results 11 to 20 of about 2,026,322 (268)

CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)

Cells, 2019
Metastasis is the main cause of cancer-related death owing to the blood-borne dissemination of circulating tumor cells (CTCs) early in the process.
Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Agathe Aberlenc, Patrycja Pawlikowska, Françoise Farace   +5 more
doaj   +1 more source

Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis.
Athina Markou, E. Tzanikou, G. Kallergi, E. Pantazaka, V. Georgoulias, A. Kotsakis, E. Lianidou   +6 more
doaj   +1 more source

Prognostic Significance of TWIST1, CD24, CD44, and ALDH1 Transcript Quantification in EpCAM-Positive Circulating Tumor Cells from Early Stage Breast Cancer Patients

Cells, 2019
(1) Background: The aim of the study was to evaluate the prognostic significance of EMT-associated (TWIST1) and stem-cell (SC) transcript (CD24, CD44, ALDH1) quantification in EpCAM+ circulating tumor cells (CTCs) of early breast cancer patients.
Areti Strati, Michail Nikolaou, Vassilis Georgoulias, Evi S. Lianidou   +3 more
doaj   +1 more source

Clinical Significance of PD-L1 Status in Circulating Tumor Cells for Cancer Management during Immunotherapy

Biomedicines, 2023
The approval of monoclonal antibodies against programmed death-ligand 1 (PD-L1) and programmed cell death protein (PD1) has changed the landscape of cancer treatment. To date, many immune checkpoint inhibitors (ICIs) have been approved by the FDA for the
Areti Strati, Panagiota Economopoulou, Evi Lianidou, Amanda Psyrri   +3 more
doaj   +1 more source

Unconventional Protein Secretion in Brain Tumors Biology: Enlightening the Mechanisms for Tumor Survival and Progression

Frontiers in Cell and Developmental Biology, 2022
Non-canonical secretion pathways, collectively known as unconventional protein secretion (UPS), are alternative secretory mechanisms usually associated with stress-inducing conditions.
Rebeca Piatniczka Iglesia, Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Rodrigo Nunes Alves, Maria Isabel Melo Escobar, Camila Felix de Lima Fernandes, Ailine Cibele dos Santos Fortes, Maria Clara da Silva Souza, Jacqueline Marcia Boccacino, Giovanni Cangiano, Samuel Ribeiro Soares, João Pedro Alves de Araújo, Deanna Marie Tiek, Anshika Goenka, Xiao Song, Jack Ryan Keady, Bo Hu, Shi Yuan Cheng, Marilene Hohmuth Lopes   +18 more
doaj   +1 more source

A Metabolic Reprogramming Amino Acid Polymer as an Immunosurveillance Activator and Leukemia Targeting Drug Carrier for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, 2022
Compromised immunosurveillance leads to chemotherapy resistance and disease relapse of hematological malignancies. Amino acid metabolism regulates immune responses and cancer; however, a druggable amino acid metabolite to enhance antitumor ...
Changzheng Li, Xinru You, Xi Xu, Binghuo Wu, Yuye Liu, Tong Tong, Jie Chen, Yishan Li, Chunlei Dai, Zhitao Ye, Xiaobin Tian, Yan Wei, Zechen Hao, Linjia Jiang, Jun Wu, Meng Zhao   +15 more
doaj   +1 more source

Multiplex detection of ten ESR1 mutations and AKT1 E17K in breast cancer using digital PCR

The Journal of Liquid Biopsy
Introduction: ESR1 mutations are now established as a key mechanism of resistance to endocrine therapy in estrogen-receptor–positive breast cancer (ER​+ ​breast cancer) and their sensitive and specific detection in plasma-cell free DNA (plasma-cfDNA) is ...
Stavroula Smilkou, Aliki Ntzifa, Dimitra Stergiopoulou, Vasilis Georgoulias, Evi Lianidou   +4 more
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A Microfluidic System for Detecting Tumor Cells Based on Biomarker Hexaminolevulinate (HAL): Applications in Pleural Effusion

Micromachines, 2023
Malignant pleural effusion is a common clinical problem, which often occurs in cases of malignant tumors, especially in lung cancer. In this paper, a pleural effusion detection system based on a microfluidic chip, combined with specific tumor biomarker ...
Yiran Luan, Lei Li, Xiaoyi Xun, Yang Wang, Xinyue Wei, Yuqun Zheng, Zhijuan Fan, Xuguo Sun   +7 more
doaj   +1 more source

Nanotechnology Driven Cancer Chemoradiation: Exploiting the Full Potential of Radiotherapy with a Unique Combination of Gold Nanoparticles and Bleomycin

Pharmaceutics, 2022
One of the major issues in current radiotherapy (RT) is the associated normal tissue toxicity. Enhancement of the RT effect with novel radiosensitizers can address this need.
Ocean Han, Kyle Bromma, Nicholas Palmerley, Ariadne T. Bido, Mesa Monica, Abdulaziz Alhussan, Perry L. Howard, Alexandre G. Brolo, Wayne Beckham, Abraham S. Alexander, Devika B. Chithrani   +10 more
doaj   +1 more source

Synthesis and Cytotoxic Activity of the Derivatives of N-(Purin-6-yl)aminopolymethylene Carboxylic Acids and Related Compounds

Molecules, 2023
Testing a number of N-[omega-(purin-6-yl)aminoalkanoyl] derivatives of 7,8-difluoro-3,4-dihydro-3-methyl-2H-[1,4]benzoxazine in a panel of nine tumor cell lines has shown that the studied compounds exhibit high cytotoxic activity, especially against 4T1 ...
Victor P. Krasnov, Olga A. Vozdvizhenskaya, Maria A. Baryshnikova, Alexandra G. Pershina, Vera V. Musiyak, Tatyana V. Matveeva, Kseniya V. Nevskaya, Olga Y. Brikunova, Dmitry A. Gruzdev, Galina L. Levit   +9 more
doaj   +1 more source