Results 11 to 20 of about 15,400,316 (399)
TIMER2.0 for analysis of tumor-infiltrating immune cells
Nucleic Acids Res., 2020 Tumor progression and the efficacy of immunotherapy are strongly influenced by the composition and abundance of immune cells in the tumor microenvironment.
Taiwen Li +7 more
semanticscholar +1 more source
Frontiers in Physiology, 2020 Signaling pathways involve complex molecular interactions and are controled by non-linear regulatory mechanisms. If details of regulatory mechanisms are not fully elucidated, they can be implemented by different, equally reasonable mathematical ...
Janina Mothes +5 more
doaj +1 more source
Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells
Frontiers in Immunology, 2023 NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory checkpoints, such as
Francesca Romana Mariotti +6 more
doaj +1 more source
Molecular Oncology, 2017 Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades.
Gomis i Cabré, Roger, Gawrzak, Sylwia
openaire +3 more sources
Tumor cell intravasation [PDF]
American Journal of Physiology-Cell Physiology, 2016 The process of entering the bloodstream, intravasation, is a necessary step in the development of distant metastases. The focus of this review is on the pathways and molecules that have been identified as being important based on current in vitro and in vivo assays for intravasation.
Serena P H, Chiang +2 more
openaire +2 more sources
Scientific Reports, 2021 Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under osimertinib.
Aliki Ntzifa +5 more
doaj +1 more source
Detection and relevance of epigenetic markers on ctDNA: recent advances and future outlook
Molecular Oncology, 2021 Liquid biopsy, a minimally invasive approach, is a highly powerful clinical tool for the real‐time follow‐up of cancer and overcomes many limitations of tissue biopsies.
Evi Lianidou
doaj +1 more source
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
core +2 more sources
CTC-Derived Models: A Window into the Seeding Capacity of Circulating Tumor Cells (CTCs)
Cells, 2019 Metastasis is the main cause of cancer-related death owing to the blood-borne dissemination of circulating tumor cells (CTCs) early in the process.
Tala Tayoun +5 more
doaj +1 more source
Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
core +2 more sources