Results 61 to 70 of about 2,987,261 (338)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Retargeted adenoviruses for radiation-guided gene delivery [PDF]

, 2016
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz, AP Patel, BL Davidson, C Roller, Cancer Genome Atlas Research Network, D E Hallahan, DA Boothman, DA Reardon, DA Spencer, DE Hallahan, DY Dadey, F Tameire, G Bajocchi, H Hsu, H Li, H Yan, HO McCarthy, JJ Mezhir, K Daino, L N Kaliberova, LM Hendershot, M Gonzalez-Gronow, M Hamdi, M Martin, M Westphal, MA Arap, MJ Gray, N Belousova, N Mittereder, R Datta, R Stupp, R Stupp, RJ Passarella, RR Weichselbaum, S A Kaliberov, S Akli, S Mittal, S Parisi, S Takahashi, SA Kaliberov, SC Noureddini, SL Eck, SS Talibi, T Ichikawa, TA Ajith, TC He, Ulasov IV, V Kapoor, VN Krasnykh, WL Blalock, WW Zhang, X Xing, Y Touchefeu, Y Zhang, YL Tsai   +54 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Trypsin digest of cancer cells surface stimulates anti-tumor immune response better than cancer cells themselves [PDF]

, 2010
Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development.
Balashova Elena, Petr Lokhov
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The rationale for liquid biopsy in colorectal cancer: focus on circulating tumor cells [PDF]

, 2015
Capturing circulating tumor cells (CTCs) and/or circulating tumor DNA from blood, which represents a precious source of biological material derived from both primary and metastatic tumors, has been named a 'liquid biopsy'. While the circulating tumor DNA
Carletti, Raffaella, Cortesi, Enrico, DI GIOIA, Cira Rosaria Tiziana, Gazzaniga, Paola, Gradilone, Angela, Nicolazzo, Chiara, Raimondi, Cristina   +6 more
core   +1 more source

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Frontiers in Immunology
BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted.
Nadine Landolina, Biancamaria Ricci, Irene Veneziani, Claudia Alicata, Francesca Romana Mariotti, Andrea Pelosi, Linda Quatrini, Eva Piano Mortari, Rita Carsetti, Paola Vacca, Nicola Tumino, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +13 more
doaj   +1 more source

Radiotherapy planning for glioblastoma based on a tumor growth model: Improving target volume delineation [PDF]

, 2013
Glioblastoma are known to infiltrate the brain parenchyma instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly.
Ayache, Nicholas, Dittmann, Florian, Konukoglu, Ender, Le, Matthieu, Menze, Bjoern H., Shih, Helen A., Unkelbach, Jan   +6 more
core   +4 more sources

T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma

Frontiers in Immunology
Neuroblastoma (NB) is an immunologically “cold” tumor with poor or no inflamed substrates as most of solid pediatric tumors (SPT). Consistent data indicate that NB tumor microenvironment (TME) is dominated by myeloid cells, with little (but variable) T ...
Enrico Maggi, Nadine Landolina, Enrico Munari, Francesca Romana Mariotti, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta   +7 more
doaj   +1 more source

Detection of Androgen Receptor Variant 7 (ARV7) mRNA Levels in EpCAM-Enriched CTC Fractions for Monitoring Response to Androgen Targeting Therapies in Prostate Cancer

Cells, 2019
Expression of the androgen receptor splice variant 7 (ARV7) in circulating tumor cells (CTCs) has been associated with resistance towards novel androgen receptor (AR)-targeting therapies. While a multitude of ARV7 detection approaches have been developed,
Claudia Hille, Tobias M. Gorges, Sabine Riethdorf, Martine Mazel, Thomas Steuber, Gunhild Von Amsberg, Frank König, Sven Peine, Catherine Alix-Panabières, Klaus Pantel   +9 more
doaj   +1 more source