Results 61 to 70 of about 15,400,316 (399)

PIK3CA hotspot mutations in circulating tumor cells and paired circulating tumor DNA in breast cancer: a direct comparison study

Molecular Oncology, 2019
Liquid biopsy analysis, mainly based on circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), provides an extremely powerful tool for the molecular profiling of cancer patients in real time.
Eleni Tzanikou, Athina Markou, Eleni Politaki, Anastasios Koutsopoulos, Amanda Psyrri, Dimitris Mavroudis, Vassilis Georgoulias, Evi Lianidou   +7 more
doaj   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Ethical Implications in the Use of Embryonic and Adult Neural Stem Cells

Stem Cells International, 2012
The advent and growth of technological advances have led to new routes of knowledge. Thereby, we currently face new challenges. We have just started to get a glimpse of the structural and functional role of neural stem cells in differentiation and ...
Rodrigo Ramos-Zúñiga, Oscar González-Pérez, Ana Macías-Ornelas, Vivian Capilla-González, Alfredo Quiñones-Hinojosa   +4 more
doaj   +1 more source

miR-371b-5p-Engineered Exosomes Enhances Tumor Inhibitory Effect

Frontiers in Cell and Developmental Biology, 2021
Background: Exosomes are well-known natural nanovesicles, that represent one of the recently discovered modes of intercellular communication due to their ability to transmit cellular components.
Qiang Xue, Yang Yang, Linlin Yang, Xiaodi Yan, Zihao Shen, Jiajia Liu, Jianhua Xue, Wei Zhao, Xianchen Liu   +8 more
doaj   +1 more source

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. [PDF]

, 2016
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous.
David James, C, Engler, Jane R, Ewald, Andrew J, Gong, Henry, Huillard, Emmanuelle, Koshkakaryan, Gayane, Lindberg, Olle R, McKinney, Andrew, Molinaro, Annette M, Phillips, Joanna J, Robinson, Aaron E, Shieh, Joseph T   +11 more
core   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

Frontiers in Immunology
Innate immunity is the first line of defense against infections, including the detection and response to SARS-CoV-2. Cells of the innate system are usually activated within hours after pathogen exposure and do not generate conventional immunological ...
Enrico Maggi, Nadine Landolina, Francesca Romana Mariotti, Enrico Munari, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta   +7 more
doaj   +1 more source

Yap-lin28a axis targets let7-Wnt pathway to restore progenitors for initiating regeneration

eLife, 2020
The sox2 expressing (sox2+) progenitors in adult mammalian inner ear lose the capacity to regenerate while progenitors in the zebrafish lateral line are able to proliferate and regenerate damaged HCs throughout lifetime. To mimic the HC damage in mammals,
Zhian Ye, Zhongwu Su, Siyu Xie, Yuye Liu, Yongqiang Wang, Xi Xu, Yiqing Zheng, Meng Zhao, Linjia Jiang   +8 more
doaj   +1 more source

Effect of astragaloside Ⅳ on SK ⁃ N ⁃ SH cells damage induced by 1 ⁃ methyl ⁃ 4 ⁃ phenylpyridine in Parkinson's disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the effect of astragaloside Ⅳ on the injury of SK⁃N⁃SH cell in Parkinson's disease (PD) induced by 1 ⁃ methy ⁃ 4 ⁃ phenylpyridine (MPP＋) and its mechanism.
HUANG Xiao⁃jing, HUANG Huai, XU Zheng⁃hu, HUANG Wan⁃gang, YANG Dong⁃feng, REN He⁃cheng   +5 more
doaj   +1 more source

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells.

Cancer Research, 2018
Neutrophils play a critical role in cancer, with both protumor and antitumor neutrophil subpopulations reported. The antitumor neutrophil subpopulation has the capacity to kill tumor cells and limit metastatic spread, yet not all tumor cells are equally ...
Maya Gershkovitz, Yaki Caspi, Tanya Fainsod-Levi, Ben Katz, Janna Michaeli, Saleh Khawaled, S. Lev, L. Polyansky, M. Shaul, Ronit Vogt Sionov, L. Cohen-Daniel, R. Aqeilan, Y. Shaul, Y. Mori, R. Karni, Z. Fridlender, A. Binshtok, Z. Granot   +17 more
semanticscholar   +1 more source