Results 61 to 70 of about 14,776,627 (313)
Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells [PDF]
, 2017 Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation ...
Cippitelli, M +13 more
core +1 more source
Trafficking of T Cells into Tumors [PDF]
Cancer Research, 2014 AbstractT cells are a crucial component of the immune response to infection and cancer. In addition to coordinating immunity in lymphoid tissue, T cells play a vital role at the disease site, which relies on their efficient and specific trafficking capabilities.
Phillip K. Darcy +3 more
openaire +3 more sources
The architecture of co-culture spheroids regulates tumor invasion within a 3D extracellular matrix [PDF]
arXiv, 2020 Tumor invasion, the process by which tumor cells break away from their primary tumor and gain access to vascular systems, is an important step in cancer metastasis. Most current 3D tumor invasion assays consisted of single tumor cells embedded within an extracellular matrix (ECM). These assays taught us much of what we know today on how key biophysical
arxiv
Elastic free energy drives the shape of prevascular solid tumors [PDF]
, 2014 It is well established that the mechanical environment influences cell functions in health and disease. Here, we address how the mechanical environment influences tumor growth, in particular, the shape of solid tumors. In an in vitro tumor model, which isolates mechanical interactions between tumor cells and a hydrogel, we find that tumors grow as ...
arxiv +1 more source
Tumor growth with nutrients: stability of the tumor patches [PDF]
arXiv, 2022 In this paper, we study a tumor growth model with nutrients. The contact inhibition for the tumor cells, presented in the model, results in the evolution of a congested tumor patch. We study the regularity of the tumor patch as the nutrients' diffusion strength $D$ diminishes.
arxiv
Chinese Journal of Contemporary Neurology and Neurosurgery, 2021 Objective To investigate the anti⁃tumoral effect of ACT001, a novel antitumor compound, on the nuclear factor⁃κB (NF⁃κB) pathway and programmed cell death protein ligand 1 (PDL1) expression in U87 glioblastoma cell line.
ZHANG Jin⁃hao +9 more
doaj +1 more source
Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.
JCI Insight, 2017 In breast cancer, a key feature of peritumoral adipocytes is their loss of lipid content observed both in vitro and in human tumors. The free fatty acids (FFAs), released by adipocytes after lipolysis induced by tumor secretions, are transferred and ...
Y. Wang +20 more
semanticscholar +1 more source
Radiotherapy planning for glioblastoma based on a tumor growth model: Improving target volume delineation [PDF]
, 2013 Glioblastoma are known to infiltrate the brain parenchyma instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly.
Ayache, Nicholas +6 more
core +4 more sources
Stochastic models for tumoral growth [PDF]
Phys. Rev. E 73, 020902(R) (2006), 2006 Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion of cells at the growing edge.
arxiv +1 more source
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy
Nature, 2019 Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang +29 more
semanticscholar +1 more source