Results 51 to 60 of about 63,140,021 (193)

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, Volume 13, Issue 55, 5 October 2026.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Avaliação dos efeitos da eletroquimioterapia sobre o desenvolvimento do tumor sólido de Ehrlich em camundongos Swiss [PDF]

, 2016
Electrochemotherapy is a local anticancer treatment in which non-permeant chemotherapeutic drugs are associated with electric pulses of well-established parameters.
Rubia Monteiro de Castro Cunha
core  

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, Volume 309, Issue 10, Page 2698-2724, October 2026.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Estudo experimental sobre a disseminação linfática do tumor de Ehrlich na forma sólida em camundongos

Brazilian Journal of Veterinary Research and Animal Science, 1992
As metástases para linfonodos regionais representam fase importante na disseminação neoplásica. Os mecanismos que concorrem para este processo são pouco conhecidos, devido provavelmente à escassez de modelos experimentais adequados. O objetivo do presente estudo é o de caracterizar o tumor de Ehrlich como modelo para o estudo da disseminação linfática ...
Maria Lúcia Zaidan Dagli, José Luiz Guerra, Paulo Hilário Nascimento Saldiva   +2 more
openaire   +2 more sources

Efeito do tratamento com própolis de Scaptotrigona aff. postica sobre o desenvolvimento do tumor de Ehrlich em camundongos [PDF]

Revista Brasileira de Farmacognosia, 2010
Neste trabalho foi investigado o efeito do extrato hidroalcoolico de propolis (EHP) de Scaptotrigona aff. postica sobre o desenvolvimento do tumor de Ehrlich na forma solida, sobre a celularidade dos orgaos linfoides dos animais portadores de tumor, bem como, sobre a producao de oxido nitrico (NO) pelos macrofagos destes animais.
Araújo, Maria José A. M., Dutra, Richard P., Costa, Graciomar C., Reis, Aramys S., Assunção, Anne K. M., Libério, Silvana A., Maciel, Márcia C. G., Silva, Lucilene A., Guerra, Rosane N. M., Ribeiro, Maria N. S., Nascimento, Flávia R. F.   +10 more
openaire   +3 more sources

Traditional Uses, Phytochemistry, and Multi‐Target Pharmacological Activities of Senna alexandrina

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Senna alexandrina is a medicinally important plant with documented use across Traditional Chinese, Islamic, Ayurvedic, and Unani medicine systems. Phytochemical investigations have yielded 219 characterized compounds, predominantly anthraquinones, flavonoids, and polysaccharides, distributed across leaves, pods, and aerial parts.
Diana Afrina Rella, Khai‐Lin Hew, Yeun‐Mun Choo   +2 more
wiley   +1 more source

Valorization of Hot Trub: Extraction and Nanoparticle Encapsulation for Antitumor Applications

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Hot trub, a brewing by‐product, is valorized through optimized extraction of phenolic compounds and encapsulation in zein nanoparticles. The polyphenol‐rich extract shows antioxidant and photoprotective activity (SPF 13.84), while zein‐based nanocarriers, particularly chitosan‐ and caseinate‐coated variants, extend its effect on MCF‐7 breast cancer ...
Lilian Tatiani Dusman Tonin, Isabella Salvat Luccas, Gabriela Barbosa da Silva, Giovanna Martins Domingos, Grazielle Jesus dos Santos, Elisângela Düsman, Ana Beatriz Sousa Santana, Patricia Aline Bressiani, Ágatha Giovanna Fragoso, Angélica Priscila Parussolo Tonin, Eduardo César Meurer   +10 more
wiley   +1 more source

Atividade antitumoral das associações de vitamina C com vitamina K3, microencaspuladas ou com ortovanadato de sódio [PDF]

, 2013
tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013Introdução: A vitamina C (VC) e vitamina K3 (VK3) têm atividade citotóxica, antiproliferativa e ...
Günther, Tânia Mara Fischer
core  

Vengeful Vines: Cell Death and Neoplasm Formation in Aristolochia (Aristolochiaceae, Piperales) in Response to Oviposition of Troidini (Papilionidae, Lepidoptera) Butterflies

Ecology and Evolution, Volume 16, Issue 10, October 2026.
This study investigates the oviposition ecology of the iconic Troidini butterflies on their host plants of the genus Aristolochia in Sabah, where we made the first observation of HR‐like cell death and neoplasm formation in response to oviposition of Troidini, signifying the first such record in the entire Magnoliid clade (> 10,000 spp.).
Veerle van Beeck, Justinah Parantis, Berber E. Zandstra, Tjomme Fernhout, Arthur Chung, Nazirah Mustaffa, Nina E. Fatouros, Corné F. H. van der Linden   +7 more
wiley   +1 more source

Associations of Serum Per‐ and Polyfluoroalkyl Substances (PFAS) With Epigenetic Age and DNA Methylation in US Airport Firefighters

Environmental and Molecular Mutagenesis, Volume 67, Issue 8-9, October-November 2026.
ABSTRACT Per‐ and polyfluoroalkyl substances (PFAS) are synthetic chemicals used in a variety of consumer and industrial applications for their water‐ and oil‐resistant properties. Firefighters can be exposed to PFAS as part of their job through gear, aqueous film‐forming foams (AFFFs) used to extinguish aircraft and liquid fuel fires, along with ...
Lauren M. Ward, Jaclyn M. Goodrich, Miriam M. Calkins, Shawn C. Beitel, Antonia M. Calafat, Alberto J. Caban‐Martinez, Paola Louzado‐Feliciano, Julianne Cook Botelho, Melissa Furlong, Randy Krause, Rob Matthis, Jeff Hughes, Jefferey L. Burgess   +12 more
wiley   +1 more source