Results 41 to 50 of about 10,767 (163)

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Del diagnóstico genético al manejo oncológico: a propósito de un caso de tumor de Wilms con trombosis renal en síndrome WAGR

Revista de la Facultad de Medicina Humana
El tumor de Wilms es el cáncer renal más frecuente en pediatría, con cerca del 90% de los casos. Presentamos el caso de una niña de 4 años con aniridia bilateral congénita, en quien se confirmó síndrome de WAGR por cariotipo en su primer año de vida.
Luis Jara-Marengo, Heidy L. Ascona-Mucha, Cesar Macha-Obregón, Fanny Yovana Tarrillo Leiva, Ivan Mazza Medina   +4 more
doaj   +1 more source

Proteína p53 em nefroblastomas

Acta Cirúrgica Brasileira, 2000
A imunoexpressão do antígeno p53 foi estudada em 35 pacientes com idade média de 38± 29 meses. Todos foram tratados com nefrectomia e quimioterapia, em 17 se associou também a radioterapia. O tempo médio de seguimento foi de 69± 66 meses.
Ricardo Iwakura, Antonio Carlos Pereira Martins, Silvio Tucci Jr, Monica T. Pastorello, Haylton Jorge Suaid, Adauto José Cologna, João José Carneiro, Antônio D. Campos   +7 more
doaj   +1 more source

Whole exome sequencing identified a rare WT1 loss‐of‐function variant in a non‐syndromic POI patient

Molecular Genetics & Genomic Medicine, 2022
Background Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of cases can be explained by genetic causes. The transcription factor WT1 has long been reported to play a crucial role in ovary function.
Yingchen Wang, Qing Chen, Feng Zhang, Xi Yang, Lingyue Shang, Shuting Ren, Yuncheng Pan, Zixue Zhou, Guoqing Li, Yunzheng Fang, Li Jin, Yanhua Wu, Xiaojin Zhang   +12 more
doaj   +1 more source

Mapping the Knowledge Structure and Thematic Trends of Wilms Tumor: Insights From Text Mining

Organ Medicine, EarlyView.
This scientometric analysis of Wilms tumor research from 1945 to 2024 highlights United States research leadership, limited international collaboration, and emerging hotspots in biomarkers, nephron‐sparing surgery, and immunotherapy. ABSTRACT Background Wilms tumor (WT), also known as nephroblastoma, is one of the most common renal malignancies in ...
Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang, Xiaohui Wang   +4 more
wiley   +1 more source

Tumores renais e adrenais com invasão cardíaca: resultados cirúrgicos imediatos em 14 pacientes Tumores renales y adrenales con invasión cardiaca: resultados quirúrgicos inmediatos en 14 pacientes Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patients

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: A ressecção do trombo tumoral em veia cava inferior (VCI) e átrio direito (AD) aumenta a sobrevida do paciente com câncer renal/supra-renal. OBJETIVO: Avaliar a conduta cirúrgica do trombo da VCI e AD no tratamento dos tumores renais e supra ...
Rafael Fagionato Locali, Priscila Katsumi Matsuoka, Tiago Cherbo, Edmo Atique Gabriel, Enio Buffolo   +4 more
doaj   +1 more source

MicroRNA‐130a‐3p Targets the Androgen‐Related Transcription Factor MAFB: Effects on Proliferation, Migration, Apoptosis, and Cell Cycle in Hypospadias

Pediatric Discovery, EarlyView.
MicroRNA‐130a‐3p targets and inhibits MAFB expression, leading to the development of hypospadimas. MicroRNA‐130a‐3p inhibits the expression of MAFB, disrupts the normal processes of cell proliferation, migration, cell apoptosis, and cycle progression, and ultimately leads to the development of hypospadias.
Jiaxin Zhou, Yixuan Wang, Zhicheng Zhang, Qiang Zhang, Zhenmin Liu, Hongsong Chen, Xingguo Luo, Chunlan Long, Lianju Shen, Xing Liu, Guanghui Wei   +10 more
wiley   +1 more source

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source

Tumor primitivo neuroectodérmico de rim em criança

Jornal de Pediatria, 2001
Objetivos: Caracterizar o tumor primitivo neuroectodérmico de rim como diagnóstico diferencial de tumor de Wilms e enfatizar a gravidade da doença. Métodos: Apresentamos um paciente com diagnóstico de tumor primitivo neuroectodérmico de rim, submetido a ...
Ana P. Kuczynski, Elizabeth S. Gugelmin, Rodrigo A.S. Netto   +2 more
doaj   +1 more source