Results 61 to 70 of about 10,767 (163)

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression

Cell Proliferation, EarlyView.
Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen, Xin Qi, Shanshan Qin, Jia Kang, Changhuo Cen, Miao Guo, Yang Gao, Mengyue Wang, Jiayi Li, Xiuhong Cui, Yanbo Wang, Lan Zhu, Fei Gao   +12 more
wiley   +1 more source

Cisto multilocular renal

Revista do Colégio Brasileiro de Cirurgiões
O cisto multilocular renal é uma tumoração rara, de etiopatogenia discutida, que apresenta um aspecto macroscópico característico (parecendo favos de mel) mas histologia variável, o que ocasionou uma vasta sinonímia para esta afecção.
Ennio Gabriel, Wilberto Trigueiro, Dailton Medeiros, Vamberto Costa Filho, Sandra Bonfim Silva Barbosa, Alexandre Aranha Trigueiro   +5 more
doaj   +1 more source

HMGA2 is a highly sensitive marker for DICER1‐related tumours

Histopathology, EarlyView.
Aims DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1‐related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent‐onset tumours.
Paul S. Thorner, Anne‐Laure Chong, Naciba Benlimane, Lili Fu, Marc R. Fabian, William D. Foulkes   +5 more
wiley   +1 more source

WTAP‐mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy

Journal of Diabetes Investigation, EarlyView.
NPWT significantly increases the suppressed WTAP and m6A levels in DFU patients, correlating directly with better 4‐week healing outcomes. In vitro, negative pressure reverses high‐glucose‐induced WTAP downregulation, restoring the cell proliferation and migration necessary for wound repair.
Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen   +6 more
wiley   +1 more source

Tumor de Wilms: Hallazgo coincidente

Salud Uninorte, 2006
El tumor de Wilms o nefroblastoma representa el 6% de los cánceres infantiles y se considera la formación abdominal y renal maligna más frecuente en la edad pediátrica.
Jaime Galindo López, Nelly Lecompte Beltrán, Lila Visbal Spirko, Adriana Consuegra Gallo   +3 more
doaj  

Aniridia congénita

Repertorio de Medicina y Cirugía, 2011
Objetivo: presentar un caso de aniridia congénita bilateral asociada con catarata e hipoplasia foveal y revisar la literatura existente. Métodos: revisión de la literatura y de la historia clínica de un paciente que consultó al Hospital de San José de ...
Adriana Solano, Juan Díaz Granados, Ángela Castillo   +2 more
doaj   +1 more source

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction.
Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Renal nephroblastoma in adults: a case report

Acta Médica del Centro, 2013
Renal nephroblastoma is a solid tumor common in childhood that has an annual incidence of 7.8 per million children under 15 years of age, with a peak age of onset in the third year of life. Its incidence in adults is extremely rare and is estimated
Esther Gilda González Carmona, Oscar Bonilla Oliva, Marcos Chaviano Hernández   +2 more
doaj