Results 61 to 70 of about 11,107 (213)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Tumor de Wilms en niños de Costa Rica

Acta Médica Costarricense, 2020
Objetivo: describir las características clínicas del grupo de niños diagnosticados con tumor de Wilms en Costa Rica y cuál es la evolución clínica de acuerdo con los diversos tratamientos que reciben en el Servicio de Oncohematología del Hospital Nacional de Niños.Métodos: este es un estudio descriptivo retrospectivo que analiza un periodo de 20 años ...
Quirós Mata, Mónica, Gamboa-Chaves, Ana Yéssika   +1 more
openaire   +3 more sources

Tumor de Wilms del adulto [PDF]

, 2015
Se presenta y se comenta un caso de un paciente de 24 años con un tumor de Wilms en el adulto, así como el diagnóstico positivo y diferencial y la terapéutica empleada con mayor frecuencia en esta enfermedad.
Fernández Marichal, Fernando, Pila Pérez, Rafael, Rosales Torres, Pedro, Pila Peláez, Rafael, Vázquez Drake, Charles   +4 more
core   +1 more source

MicroRNA‐130a‐3p Targets the Androgen‐Related Transcription Factor MAFB: Effects on Proliferation, Migration, Apoptosis, and Cell Cycle in Hypospadias

Pediatric Discovery, EarlyView.
MicroRNA‐130a‐3p targets and inhibits MAFB expression, leading to the development of hypospadimas. MicroRNA‐130a‐3p inhibits the expression of MAFB, disrupts the normal processes of cell proliferation, migration, cell apoptosis, and cycle progression, and ultimately leads to the development of hypospadias.
Jiaxin Zhou, Yixuan Wang, Zhicheng Zhang, Qiang Zhang, Zhenmin Liu, Hongsong Chen, Xingguo Luo, Chunlan Long, Lianju Shen, Xing Liu, Guanghui Wei   +10 more
wiley   +1 more source

FISH studies in a girl with sporadic aniridia and an apparently balanced de novo t(11;13)(p13;q33) translocation detect a microdeletion involving the WAGR region

Genetics and Molecular Biology, 2000
Conventional cytogenetic studies on a female infant with sporadic aniridia revealed what appeared to be a balanced de novo t(11;13) (p13;q33) translocation.
J.C. Llerena Jr., J.C. Cabral de Almeida, E. Bastos, J.A. Crolla   +3 more
doaj   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Whole exome sequencing identified a rare WT1 loss‐of‐function variant in a non‐syndromic POI patient

Molecular Genetics & Genomic Medicine, 2022
Background Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of cases can be explained by genetic causes. The transcription factor WT1 has long been reported to play a crucial role in ovary function.
Yingchen Wang, Qing Chen, Feng Zhang, Xi Yang, Lingyue Shang, Shuting Ren, Yuncheng Pan, Zixue Zhou, Guoqing Li, Yunzheng Fang, Li Jin, Yanhua Wu, Xiaojin Zhang   +12 more
doaj   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source