Results 51 to 60 of about 10,767 (163)
Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity
Phytotherapy Research, EarlyView.Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun +5 more
wiley +1 more source
Interventional oncology in children: Where are we now?
Journal of Medical Imaging and Radiation Oncology, EarlyView.Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel +1 more
wiley +1 more source
Allergy, EarlyView.This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in HDM‐induced AR, focusing on ferroptosis‐related responses and nasal epithelial barrier disruption. HDM exposure induces lipid peroxidation‐driven ferroptosis and epithelial barrier disruption.
Zehua Lin +9 more
wiley +1 more source
Cirugía Preservadora de Nefronas en Tumor de Wilms Bilateral.
Revista Guatemalteca de Urología, 2018 El WT bilateral generalmente se ha tratado con nefrectomía radical (RN) del riñón más afectado y cirugía preservadora de nefrona en el riñón contralateral menos afectado después de la quimioterapia neoadyuvante.
Celeste Alston +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley +1 more source
Tumor de Wilms' na criança: revisão de 38 casos.
Acta Médica Portuguesa, 1991 Analysis of the incidence of the Nephroblastoma and of its clinic, echographic and radiologic aspects. Review of 38 cases handled in the Pediatric Surgery Service of Santa Maria Hospital between January 1960 and January 1987.
M J Leal +3 more
doaj +1 more source
m6A‐Mediated Stabilization of MRPS23 Drives NSCLC Progression Via HSPA8 and ERK Signaling Modulation
Cancer Science, EarlyView.MRPS23 mRNA is m6A‐methylated by WTAP and stabilized by IGF2BP3, leading to increased MRPS23 protein. MRPS23 physically interacts with HSPA8, and this interaction is functionally associated with activation of the RAS–RAF–MEK–ERK pathway, ultimately promoting NSCLC cell proliferation and tumor progression.
Sihong Le +4 more
wiley +1 more source
Wilms’ Tumor in children treated at the provincial pediatric hospital of Holguín
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020 Background: Wilms’ tumor is a malignant neoplasia whose origin has been attributed to disorders in the renal histogenesis. It has been described as the fifth malignant neoplasia in pediatrics; it is the commonest renal tumor.Objective: to describe a ...
Onelis Góngora-Gómez +4 more
doaj
Cancer Science, EarlyView.Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley +1 more source