Results 71 to 80 of about 48,342,326 (223)

Whole exome sequencing identified a rare WT1 loss‐of‐function variant in a non‐syndromic POI patient

Molecular Genetics & Genomic Medicine, 2022
Background Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of cases can be explained by genetic causes. The transcription factor WT1 has long been reported to play a crucial role in ovary function.
Yingchen Wang, Qing Chen, Feng Zhang, Xi Yang, Lingyue Shang, Shuting Ren, Yuncheng Pan, Zixue Zhou, Guoqing Li, Yunzheng Fang, Li Jin, Yanhua Wu, Xiaojin Zhang   +12 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Tumor de Wilms del adulto [PDF]

, 2015
Se presenta y se comenta un caso de un paciente de 24 años con un tumor de Wilms en el adulto, así como el diagnóstico positivo y diferencial y la terapéutica empleada con mayor frecuencia en esta enfermedad.
Fernández Marichal, Fernando, Pila Pérez, Rafael, Rosales Torres, Pedro, Pila Peláez, Rafael, Vázquez Drake, Charles   +4 more
core  

Wilms’ Tumour – Histology and Differential Diagnosis

, 2016
Wilms’ tumour (WT) is the most common paediatric renal tumour, which can present as a single nodule, as multifocal unilateral lesions or as bilateral tumours. Typically, WT comprises three histological components namely blastemal, epithelial and stromal.

core   +1 more source

Clinical and genetic features of pediatric hereditary polyposis syndromes in Israel: A nationwide multicenter cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long‐term risk of malignancy. Current data on their presentation, management, and outcomes in pediatric populations remain limited.
Shlomi Cohen, Tal Cozacov, Ilana Weintraub, Ron Shaoul, Oren Ledder, Dotan Yogev, Mordechai Slae, Ranya Egbarieh, Galina Ling, Anat Yerushalmy‐Feler   +9 more
wiley   +1 more source

LOSS OF HETEROZYGOSITY ANALYSIS AT DIFFERENT CHROMOSOME REGIONS IN WILMS TUMOR CONFIRMS 1P ALLELIC LOSS AS A MARKER OF WORSE PROGNOSIS: A STUDY FROM THE ITALIAN ASSOCIATION OF PEDIATRIC HEMATOLOGY AND ONCOLOGY

, 2013
PURPOSE: The specific aims of the AIEOP-TW-2003 protocol included prospectively investigating a possible association of tumor loss of heterozygosity with outcomes in children treated for Wilms tumor.
Nantron M, AIEOP Wilms Tumor Working Group, PESSION, ANDREA, D'Angelo P, Indolfi P, Morosi C, Radice P, Di Cataldo A, Mariani L, Terenziani M, Perotti D, Gamba B, Collini P, Spreafico F   +13 more
core   +1 more source

Del diagnóstico genético al manejo oncológico: a propósito de un caso de tumor de Wilms con trombosis renal en síndrome WAGR

Revista de la Facultad de Medicina Humana
El tumor de Wilms es el cáncer renal más frecuente en pediatría, con cerca del 90% de los casos. Presentamos el caso de una niña de 4 años con aniridia bilateral congénita, en quien se confirmó síndrome de WAGR por cariotipo en su primer año de vida.
Luis Jara-Marengo, Heidy L. Ascona-Mucha, Cesar Macha-Obregón, Fanny Yovana Tarrillo Leiva, Ivan Mazza Medina   +4 more
doaj   +1 more source

Proteína p53 em nefroblastomas

Acta Cirúrgica Brasileira, 2000
A imunoexpressão do antígeno p53 foi estudada em 35 pacientes com idade média de 38± 29 meses. Todos foram tratados com nefrectomia e quimioterapia, em 17 se associou também a radioterapia. O tempo médio de seguimento foi de 69± 66 meses.
Ricardo Iwakura, Antonio Carlos Pereira Martins, Silvio Tucci Jr, Monica T. Pastorello, Haylton Jorge Suaid, Adauto José Cologna, João José Carneiro, Antônio D. Campos   +7 more
doaj   +1 more source

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO‐Mediated N6‐Methyladenosine Demethylation of ACSL1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Ai‐Xia Song, Han‐Xu Jin, Yuan‐Xin Sun, Wen‐Hui Kou, Xiao‐Ning Niu, Huan‐Huan Wang, Ting‐Ting Zhong, Ping Gu   +7 more
wiley   +1 more source

Tumores renais e adrenais com invasão cardíaca: resultados cirúrgicos imediatos em 14 pacientes Tumores renales y adrenales con invasión cardiaca: resultados quirúrgicos inmediatos en 14 pacientes Renal and adrenal tumors with cardiac invasion: immediate surgical results in 14 patients

Arquivos Brasileiros de Cardiologia, 2009
FUNDAMENTO: A ressecção do trombo tumoral em veia cava inferior (VCI) e átrio direito (AD) aumenta a sobrevida do paciente com câncer renal/supra-renal. OBJETIVO: Avaliar a conduta cirúrgica do trombo da VCI e AD no tratamento dos tumores renais e supra ...
Rafael Fagionato Locali, Priscila Katsumi Matsuoka, Tiago Cherbo, Edmo Atique Gabriel, Enio Buffolo   +4 more
doaj   +1 more source