Results 81 to 90 of about 10,767 (163)

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Adenoma metanéfrico atípico: Reporte de un caso pediátrico

Revista Médica Herediana
El adenoma metanéfrico (AM) es un tipo extremadamente raro de tumor renal en pediatría. Se reporta el caso de una niña de dos años con antecedente de infecciones urinarias recurrentes.
Mayron D. Nakandakari, Eliana Torres-Rosas, Alan Latorre-Zúñiga, William Carreño-Reymundo   +3 more
doaj   +1 more source

Conformational stability and domain‐specific structural features of tumor autoantigens regulate autoantibody epitope propensity

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Autoantibodies against tumor‐associated autoantigens are clinically valuable biomarkers for cancer diagnosis; however, the structural determinants governing epitope selectivity remain unknown. Here, we investigated whether the intrinsic conformational stability of target autoantigens regulates the epitope propensity of tumor‐associated ...
Ai Miyamoto, Rika Yamamoto, Ryui Sakaguchi, Rikako Kutsuma, Takeru Mori, Mirei Masui, Tomoko Honjo, Midori Futami, Mariko Morii, Hiromi Watanabe, Tadahiro Kuribayashi, Kadoaki Ohashi, Katsuyuki Kiura, Junichiro Futami   +13 more
wiley   +1 more source

Carcinoma cortical suprarrenal pediátrico con sobreexpresión de p53

Anales de la Facultad de Medicina
El carcinoma cortical suprarrenal es una neoplasia maligna pediátrica extremadamente rara, que suele presentar manifestaciones hormonales. El diagnóstico suele ser en estadios avanzados y el curso de la enfermedad es agresivo.
José Richard Tenazoa-Villalobos, Sofía Leonor Prado-Cucho, Mercedes Bravo-Taxa, Edgar Fermín Yan-Quiroz, Luis Taxa-Rojas   +4 more
doaj   +1 more source

Dynamic Prediction of Clinical Endpoints in Survival Analysis With Machine and Deep Learning: A Systematic Review and Regulatory Perspective

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Accurate prediction of time‐to‐event outcomes is essential for clinical decision‐making and model‐informed drug development (MIDD). Conventional survival models may inadequately represent complex longitudinal patient trajectories, time‐dependent treatments, and evolving biomarker or pharmacokinetic/pharmacodynamic (PK/PD) profiles.
Xinyi Liu, Shuai Shao, Dorothee Semiond, Malidi Ahamadi   +3 more
wiley   +1 more source

Tumor de Wilms con invasión de vena cava

Cirugía del Uruguay, 1981
Se presenta un caso de trombosis neoplásica de la vena cava inferior, uor nefroblastoma de-1·echo en una niña de 2- años, que fue tratada por nefrectomía ensanchada, extracción del trombo, quimioterapia y radioterapia, con una buena evolución a los 22 ...
Raúl Cepellini, Daniel Torres, César Arruti, Juana M Wettstein, Oscar Chavarría, Dora Ravera de Bengochea, Luis Falconi, Eduardo Anavitarte   +7 more
doaj  

A DRACH Observed/Expected Metric Reveals the Evolutionary Landscape of Epitranscriptomic Regulation Across Bilateria

Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.
Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet, Jérémy Le Luyer, Hélène Auger, Maximilian Haeussler, Guillaume Rivière   +4 more
wiley   +1 more source

Pleural Mesothelioma With Unusual Squamous Differentiation: A Clinicopathological Case Report With Molecular Insights From Whole‐Exome Sequencing

Pathology International, Volume 76, Issue 10, October 2026.
This case report highlights a rare histological variant of pleural mesothelioma with partially squamous differentiation in an 81‐year‐old man with occupational asbestos exposure. In addition to histological, immunohistochemical and fluorescence in situ hybridization analyses, indicating a common mesothelial origin of both tumor components, whole‐exome ...
Julius Bodemeyer, Mara Elisa Mierzwa, Jörg Seraphin, Rizkallah Maroun, Wolfgang Körber, Christoph Engelke, Felix Bremmer, Tessa Rosenthal, Tim Heißenberg, Kirsten Reuter‐Jessen, Philipp Ströbel, Alexander Marx, Hanibal Bohnenberger   +12 more
wiley   +1 more source

Tratamiento quirúrgico del cáncer de riñón del adulto y del niño

Cirugía del Uruguay, 1974
Los autores hacen un estudio del tratamiento quirúrgico del cáncer renal en el adulto y en el niño. Subrayan el interés del abordaje toracoabdominal.
Omar Clarck, Ruben Sierra
doaj  

Increase in podocyte number induced by SV40T antigen during the fetal stage does not expand glomerular size in mice

Physiological Reports, Volume 14, Issue 19, October 2026.
Introduction of SV40 large T antigen (SV40T) in embryonic mouse podocytes via a Tet‐On system markedly increased podocyte number at birth (P0). However, the supernumerary podocytes formed multilayers and detached into the urinary space, failing to enlarge the glomerular tuft area.
Taiji Matsusaka, Koichiro Ichimura, Takayuki Miyaki, Masahiro Koizumi   +3 more
wiley   +1 more source