Results 141 to 150 of about 26,291 (288)

Unraveling the Mystery of Breast Cancer Dormancy: Insights into Genetic, Receptor, and Cellular Interactions Driving Late Recurrence

Frontiers in Immunology
Late recurrence of breast cancer poses a considerable threat to patient survival, often attributed to breast cancer dormancy. Dormancy, characterized by cancer cells remaining quiescent for extended periods, is influenced by genetic factors and ...
Haochen Ma, Bingqiang Zhang, Mengmeng Chen, Zhendi Song, Yi Zhao   +4 more
doaj   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Could senescence phenotypes strike the balance to promote tumor dormancy? [PDF]

Cancer Metastasis Rev, 2023
Chiu FY, Kvadas RM, Mheidly Z, Shahbandi A, Jackson JG.   +4 more
europepmc   +1 more source

Molekulare Charakterisierung von »Tumor-Dormancy« beim Pankreaskarzinom

, 2004
Objective: A human pancreatic adenocarcinoma cell line (A818-6) — which shows all typical genetic alterations of malignant cells — develops single layer epithelial hollow spheres resembling normal pancreatic ductal structures in vitro. In this highly differentiation state of hollow sphere formation, A818-6 cells are showing growth arrest and a decrease
Voss, M, Paulsen, H, von Boetticher, J, Lehnert, L, Kalthoff, H   +4 more
openaire   +2 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

KISS1 metastasis suppressor in tumor dormancy: a potential therapeutic target for metastatic cancers? [PDF]

Cancer Metastasis Rev, 2023
Harihar S, Welch DR.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bridging the Gap in Breast Cancer Dormancy: Models, Mechanisms, and Translational Challenges

Pharmaceuticals
Breast cancer (BC) poses a significant clinical challenge due to late metastatic recurrence, driven by dormant disseminated tumor cells (DTCs). This review emphasizes the urgency of addressing tumor dormancy to reduce metastatic relapse, a major ...
Hussein Sabit, Shaimaa Abdel-Ghany, Yasser Albrahim, Al-Hassan Soliman Wadan, Sanaa Rashwan, Rebekka Arneth, Borros Arneth   +6 more
doaj   +1 more source

Tumor dormancy is closely related to prognosis prediction and tumor immunity in neuroblastoma. [PDF]

Transl Pediatr, 2023
Tian X, Cao F, Li X, He Y, Xia Y, Chen L, Zhao Q.   +6 more
europepmc   +1 more source