Results 191 to 200 of about 1,368,638 (269)

SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity. [PDF]

Cell Rep
Zhong Y, Mazik L, Su H, Chiang CY, Geng F, Mo X, Wang Q, Kou Y, Chen W, Li Z, Horbinski C, Chakravarti A, Wang QE, Guo D.   +13 more
europepmc   +1 more source

Real‐World Trends in Prenatal Antirheumatic Drug Utilization in Ontario, Canada: A Cross‐Sectional Time‐Series Analysis

Arthritis Care &Research, EarlyView.
Objective This study aimed to describe real‐world trends in preconception and prenatal use of antirheumatic drugs among pregnant individuals with rheumatic diseases in Ontario, Canada. Methods We conducted a time‐series analysis using repeated cross‐sectional data to examine annual patterns of disease‐modifying antirheumatic drug (DMARD) use among ...
Shenthuraan Tharmarajah, Swaleh Hussain, Sara J. T. Guilcher, Lisa M. McCarthy, Dharini Mahendira, Howard Berger, Mina Tadrous   +6 more
wiley   +1 more source

CCL3 is produced by aged neutrophils across cancers and promotes tumor growth. [PDF]

Cancer Cell
Bolli E, Wirapati P, Hicham M, Xie Y, Siwicki M, Duval F, Goubet AG, Kiss M, Zitti B, Zwahlen T, Mcdowell S, Bill R, Angerani S, Engblom C, Anderson S, Jiang A, Hartley O, Sykes DB, Jankovic M, Fournier N, Gunzer M, Tarussio D, Tissot S, Sadow PM, Faquin WC, Sade-Feldman M, Weissleder R, Pai S, Mercier F, Manguso R, Pittet MJ.   +30 more
europepmc   +1 more source

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth. [PDF]

Sci Adv
Qin M, Shang L, Chen H, Shi L, Liu C, Ding M, He D, Shao C, Yuan S, Yu H, Hao H, Ma Y, Xiong J.   +12 more
europepmc   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Stretching inhibits tumor growth in MMTV-PYMT via a direct mechanical effect. [PDF]

BMC Biol
Berrueta L, Bhan C, He Y, Thompson RD, Safairad O, Doyle AD, Pérez P, Martin D, Mezher M, Cartagena-Rivera A, Badger GJ, Langevin HM.   +11 more
europepmc   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

NFYC upregulates KLF1 expression and activate LDHA to drive glycolysis and tumor growth in glioblastoma cells. [PDF]

Front Cell Dev Biol
Fang Y, Yang Y, Lv Z, Yan J, Li P, Ni W.
europepmc   +1 more source