Results 131 to 140 of about 3,283,768 (383)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

Nature Communications
Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis.
Christel F. A. Ramirez, Daniel Taranto, Masami Ando-Kuri, Marnix H. P. de Groot, Efi Tsouri, Zhijie Huang, Daniel de Groot, Roelof J. C. Kluin, Daan J. Kloosterman, Joanne Verheij, Jing Xu, Serena Vegna, Leila Akkari   +12 more
doaj   +1 more source

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Frontiers in Immunology
BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted.
Nadine Landolina, Biancamaria Ricci, Irene Veneziani, Claudia Alicata, Francesca Romana Mariotti, Andrea Pelosi, Linda Quatrini, Eva Piano Mortari, Rita Carsetti, Paola Vacca, Nicola Tumino, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +13 more
doaj   +1 more source

The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation

Stem Cell Research & Therapy, 2021
Background The liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has not been elucidated.
Changchun Shao, Xue Yang, Yingying Jing, Xiaojuan Hou, Yihua Huang, Chen Zong, Lu Gao, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Rong Li, Xiaoren Zhang, Lixin Wei   +14 more
doaj   +1 more source

Label-Free Liver Tumor Segmentation [PDF]

arXiv, 2023
We demonstrate that AI models can accurately segment liver tumors without the need for manual annotation by using synthetic tumors in CT scans. Our synthetic tumors have two intriguing advantages: (I) realistic in shape and texture, which even medical professionals can confuse with real tumors; (II) effective for training AI models, which can perform ...
arxiv  

Serafino Zappacosta: An Enlightened Mentor and Educator. [PDF]

, 2020
With this article, the authors aim to honor the memory of Serafino Zappacosta, who had been their mentor during the early years of their career in science.
Carbone, Ennio, D'Oro, Ugo, De Felice, Mario, Di Rosa, Francesca, Fontana, Silvia, La Cava, Antonio, Maio, Michele, Matarese, Giuseppe, Racioppi, Luigi, Ruggiero, Giuseppina, Terrazzano, Giuseppe   +10 more
core   +1 more source

Trends and advances in tumor immunology and lung cancer immunotherapy

Journal of experimental & clinical cancer research : CR, 2016
Among several types of tumor, lung cancer is considered one of the most fatal and still the main cause of cancer-related deaths. Although chemotherapeutic agents can improve survival and quality of life compared with symptomatic treatment, cancers ...
M. Aldarouish, Cailian Wang
semanticscholar   +1 more source

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Cellular & Molecular Immunology, 2020
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but
Yuanyuan Zhang, Zemin Zhang
semanticscholar   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality

npj Breast Cancer
Cancer disrupts intratumoral innate-adaptive immune crosstalk, but how the systemic immune landscape evolves during breast cancer progression remains unclear. We profiled circulating immune cells in stage I–III and stage IV triple-negative breast cancer (
Noor A. M. Bakker, Hannah Garner, Ewald van Dyk, Elisa Champanhet, Chris Klaver, Maxime Duijst, Leonie Voorwerk, Iris Nederlof, Rosie Voorthuis, Marte C. Liefaard, Marja Nieuwland, Iris de Rink, Onno B. Bleijerveld, Hendrika M. Oosterkamp, Lodewyk F. A. Wessels, Marleen Kok, Karin E. de Visser   +16 more
doaj   +1 more source