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Tumor microenvironment and immunology of ovarian cancer: 12th Biennial Rivkin Center Ovarian Cancer Research Symposium [PDF]

open access: yes, 2019
The 12th Biennial Ovarian Cancer Research Symposium organized by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research held on September 13–15, 2018 covered cutting edge and relevant research topics in ovarian cancer ...
Mitra, Anirban K., Yang-Hartwich, Yang
core   +1 more source

Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells [PDF]

open access: yes, 2017
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity.
Aurelia Rughetti   +16 more
core   +8 more sources

Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling

open access: yesOncoImmunology, 2022
While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized.
Kevin Kos   +11 more
doaj   +1 more source

The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program [PDF]

open access: yes, 2011
The Society for Immunotherapy of Cancer, SITC (formerly the International Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and ...
Balwit, James M   +3 more
core   +3 more sources

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

open access: yes, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua   +4 more
core   +1 more source

Isolation of native EVs from primary biofluids—Free‐flow electrophoresis as a novel approach to purify ascites‐derived EVs

open access: yesJournal of Extracellular Biology, 2022
Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain challenging. Here we introduce free‐flow electrophoresis (FFE) as a novel approach for purifying EVs from
Christian Preußer   +11 more
doaj   +1 more source

Cancer Immunology [PDF]

open access: yes, 2022
The past decade has seen immunotherapy rise to the forefront of cancer treatment. This Special Issue of Cancers aims to elaborate on the latest developments, cutting-edge technologies, and prospects in cancer immunology and immunotherapy.

core   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls   +9 more
wiley   +1 more source

Memory NK cell features exploitable in anticancer immunotherapy [PDF]

open access: yes, 2019
Besides their innate ability to rapidly produce effector cytokines and kill virus-infected or transformed cells, natural killer (NK) cells display a strong capability to adapt to environmental modifications and to differentiate into long-lived ...
Battella, Simone   +5 more
core   +2 more sources

Isolation of Mononuclear Cell Populations from Ovarian Carcinoma Ascites

open access: yesBio-Protocol, 2017
Ovarian cancer is one of the most fatal tumors in women. Due to a lack of symptoms and adequate screening methods, patients are diagnosed at advanced stages with extensive tumor burden (Jelovac and Armstrong, 2011).
Christina Wefers   +6 more
doaj   +1 more source

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