Results 71 to 80 of about 3,274,326 (383)

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

Cancer Cell International, 2022
Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han, Lixin Wei   +8 more
doaj   +1 more source

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities [PDF]

, 2019
Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the ...
Botti L., Cappetti B., Chiodoni C., Colombo M. P., Consonni F. M., Gulino A., Nicola M. D., Portararo P., Randon G., Sangaletti S., Sica A., Talarico G., Tripodo C.   +12 more
core   +2 more sources

CART cells are prone to Fas- and DR5-mediated cell death

Journal for ImmunoTherapy of Cancer, 2018
Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that
Benjamin O. Tschumi, Nina Dumauthioz, Bastien Marti, Lianjun Zhang, Pascal Schneider, Jean-Pierre Mach, Pedro Romero, Alena Donda   +7 more
doaj   +1 more source

Neutrophils in cancer: neutral no more [PDF]

, 2016
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view.
A Blaisdell, A Carus, A Görgens, A Hasenberg, A Kohler, A Mantovani, A Sparmann, A Stoppacciaro, A Swierczak, A Warnatsch, AD Friedman, AD Panopoulos, AJ Casbon, AJ Gentles, AJ Templeton, AK Mankan, AM Houghton, AM Wengner, AP Tittel, AS Chung, B Ruffell, BK Popivanova, BT Suratt, BZ Qian, C Cheretakis, C Gordy, C Martin, CF Wu, CH Ries, CL Semerad, CL Semerad, D Di Mitri, D Marvel, D Metcalf, D Zhang, DI Gabrilovich, DJ Cua, DR Welch, E Elinav, EB Eruslanov, EI Deryugina, EM Bekes, F Chen, F Colotta, F Kuonen, F Liu, F Liu, F Rosenbauer, F Shojaei, F Shojaei, F Shojaei, F Shojaei, G Molineux, G Wang, GJ Guthrie, GJ Lieschke, GO Ahn, H Hirai, H Ji, H Katoh, H Nozawa, H Takahashi, H Tazawa, HH Yan, HK Jensen, HK Kim, HL Rao, HS Deshmukh, I Mishalian, I Petit, J Adolfsson, J Cools-Lartigue, J Crawford, J Jablonska, J Jiao, J Mei, J Pillay, J Pillay, J Pillay, J Sceneay, JC Pahler, JD Spicer, JD Waight, JD Waight, JF Seymour, JI Youn, JI Youn, JL Granick, JL Guerriero, JM Daley, JM Petty, JP Levesque, JT Dancey, JT Erler, JY Sagiv, K Fiedler, K Kersten, K Kim, K Shang, K Shitara, K Tomihara, KA Charles, Karin E. de Visser, KE De Visser, KH Steinbach, KJ Eash, KJ Eash, L Benevides, L Deng, L Gong, L Strauss, L Yang, L Yang, LA Pekarek, LB Rivera, LJ Bayne, LM Coussens, LP Seung, M Bodogai, M Bruchard, M Di Maio, M Elkabets, M Hager, M Ishikawa, M Kowanetz, M Papaspyridonos, M Santoni, M Van Egmond, M Wislez, MA Lopez-Lago, MA Postow, MA Stark, Max D. Wellenstein, MF Denny, MG Manz, MH Kim, MK Richards, MK Srivastava, MP Keane, MT O'Toole, N Antonio, N Borregaard, N Borregaard, P Andreu, P Ehrlich, P Schwarzenberger, P Wu, PC Burdon, PC Vincent, PJ Murray, Q Ma, R Bertini, R Catena, R Noy, RA Caruso, RA Droeser, RN Kaplan, S Acharyya, S Basu, S Dogan, S Hiratsuka, S Tazzyman, S Tazzyman, S Tu, SB Coffelt, SB Coffelt, SB Forlow, Seth B. Coffelt, SH Chang, SH Saverymuttu, SI Rennard, SJ Huh, SJ Moghaddam, SK Bunt, SK Wculek, SL Gaffen, SL Highfill, T Bald, T El Rayes, T Jamieson, T Kitamura, T Lämmermann, T Tak, T Voloshin, T Yamanaka, TE Sutherland, TO Jensen, V Cortez-Retamozo, V Finisguerra, VT Phan, WJ McKinstry, X Qu, X Song, XD Yang, Y Carmi, Y Han, Y Ma, Y Pang, Y Pylayeva-Gupta, Y Sawanobori, Y Tsuda, Y Ueda, Y Ueda, Z Granot, Z Li, ZG Fridlender   +205 more
core   +1 more source

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

OncoImmunology, 2020
Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined.
Eliana Marinari, Mathilde Allard, Robin Gustave, Valérie Widmer, Géraldine Philippin, Doron Merkler, Petros Tsantoulis, Valérie Dutoit, Pierre-Yves Dietrich   +8 more
doaj   +1 more source

Newly developed 3D in vitro models to study tumor–immune interaction

Journal of Experimental & Clinical Cancer Research, 2023
Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in ...
Peiyuan Mu, Shujuan Zhou, Tao Lv, Fan Xia, Lijun Shen, Juefeng Wan, Yaqi Wang, Hui Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua, Zhen Zhang   +11 more
doaj   +1 more source

Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker [PDF]

arXiv, 2022
Background: RNA guanine-7 methyltransferase (RNMT) is one of the main regulators of N7-methylguanosine, and the deregulation of RNMT correlated with tumor development and immune metabolism. However, the specific function of RNMT in pan-cancer remains unclear.
arxiv  

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

Generating counterfactual explanations of tumor spatial proteomes to discover effective strategies for enhancing immune infiltration [PDF]

arXiv, 2022
The tumor microenvironment (TME) significantly impacts cancer prognosis due to its immune composition. While therapies for altering the immune composition, including immunotherapies, have shown exciting results for treating hematological cancers, they are less effective for immunologically-cold, solid tumors.
arxiv  

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

Frontiers in Immunology, 2023
The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (Ig) repertoires.
Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C. M. van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J. I. Catsman, Iris N. Pardieck, Maaike Kreft, Ramon Arens, Jeroen E. J. Guikema, Heinz Jacobs   +12 more
doaj   +1 more source