Results 81 to 90 of about 3,274,326 (383)

Immune checkpoints in circulating and tumor-Infiltrating CD4 + T Cell Subsets in Colorectal cancer patients [PDF]

, 2019
Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach; however, it has shown limited success in some cancers including colorectal cancer (CRC). The tumor microenvironment (TME) is largely responsible for response to therapy,
Abu Nada, M, Al-Dhaheri, M, Elkord, E, Khawar, M, Murshed, K, Toor, SM   +5 more
core   +2 more sources

HLA-DR in Cytotoxic T lymphocytes predicts breast cancer patients' response to neoadjuvant chemotherapy [PDF]

, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Borralho, Paula, Braga, Sofia, Cabral, M. Guadalupe, Jacinto, António, Saraiva, Diana P.   +4 more
core   +2 more sources

Sensing Danger: Innate Immunology for Intrusion Detection [PDF]

Information Security Technical Report, 12(4), pp 218-227, 2007, 2008
The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so far with little success. However, these previous systems were largely based on immunological theory from the 1970s
arxiv   +1 more source

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources

Immunologic Treatment of Tumors.

Experimental Biology and Medicine, 1959
SummaryWe produced antibodies by injecting cancer cells obtained from Walker 256 tumor into rabbits; after several injections of the cell antigen, the rabbits were exsanguinated, and the serum fractionated. Antibodies to normal tissue were adsorbed out by exposure to normal tissue.
Eric R. Brown, John A. McCredie, Warren H. Cole   +2 more
openaire   +3 more sources

Immunological ignorance of solid tumors [PDF]

Springer Seminars in Immunopathology, 2005
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, the immune surveillance against clinically manifest carcinomas and sarcomas seems relatively inefficient.
Adrian F. Ochsenbein, Adrian F. Ochsenbein   +1 more
openaire   +4 more sources

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

Tumor microenvironment and immunology of cholangiocarcinoma

Hepatoma Research, 2022
Cholangiocarcinoma (CCA), an aggressive tumor originating from both intra- and extra-hepatic biliary cells, represents an unmet need in liver oncology, as treatment remains largely unsatisfactory. A typical feature of CCA is the presence of a complex tumor microenvironment (TME) composed of neoplastic cells, a rich inflammatory infiltrate, and cancer ...
Cadamuro M., Fabris L., Zhang X., Strazzabosco M.   +3 more
openaire   +2 more sources

The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer

Scientific Reports, 2022
Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments.
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada   +15 more
doaj   +1 more source

Learning-Based sensitivity analysis and feedback design for drug delivery of mixed therapy of cancer in the presence of high model uncertainties [PDF]

arXiv, 2022
In this paper, a methodology is proposed that enables to analyze the sensitivity of the outcome of a therapy to unavoidable high dispersion of the patient specific parameters on one hand and to the choice of the parameters that define the drug delivery feedback strategy on the other hand.
arxiv