Results 81 to 90 of about 443,774 (290)

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Genome Biology
Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two independent pathways, controlled by the polymerase REV1 and ubiquitinated PCNA, respectively ...
Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs   +13 more
doaj   +1 more source

Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials

Frontiers in Oncology, 2019
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is limited by the number of parameters that can be simultaneously analyzed, severely restricting ...
Ramy Gadalla, Babak Noamani, Bethany L. MacLeod, Russell J. Dickson, Mengdi Guo, Wenxi Xu, Sabelo Lukhele, Heidi J. Elsaesser, Albiruni R. Abdul Razak, Naoto Hirano, Naoto Hirano, Tracy L. McGaha, Tracy L. McGaha, Ben Wang, Marcus Butler, Cynthia J. Guidos, Cynthia J. Guidos, Pam S. Ohashi, Pam S. Ohashi, Lillian L. Siu, David G. Brooks, David G. Brooks   +21 more
doaj   +1 more source

Exosomes and Exosomal miRNA in Respiratory Diseases [PDF]

, 2016
Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and ...
Adcock, IM, Alipoor, SD, Garssen, J, Mirsaeidi, M, Mortaz, E, Movassaghi, M   +5 more
core   +4 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling

Cell & Bioscience, 2019
Background Babaodan (BBD), a traditional Chinese medicine, has been shown to have protective effects during liver injury and ameliorate liver disease progression, but little is known about its effect on non-alcoholic fatty liver disease (NAFLD).
Dandan Sheng, Shanmin Zhao, Lu Gao, Huifei Zheng, Wenting Liu, Jing Hou, Yuxiang Jin, Fei Ye, Qiudong Zhao, Rong Li, Naping Zhao, Li Zhang, Zhipeng Han, Lixin Wei   +13 more
doaj   +1 more source

T-cell repertoire diversity: friend or foe for protective antitumor response?

Journal of Experimental & Clinical Cancer Research, 2022
Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generation sequencing
Nicla Porciello, Ornella Franzese, Lorenzo D’Ambrosio, Belinda Palermo, Paola Nisticò   +4 more
doaj   +1 more source

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis [PDF]

, 2011
Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial ...
Antunes, RF, Dumitriu, IE, Kaski, JC
core   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Wolfberry prevented liver damage caused by anti-tuberculosis drugs associated with the YAP1/FXR pathway through gut microbiota

Frontiers in Microbiology
BackgroundThe prevalence of anti-tuberculosis drug-induced liver injury (AT-DILI) is significant, with severe cases potentially leading to liver failure or mortality. Research indicates that first-line anti-tuberculosis drugs (ATDs), including rifampicin
Dan Wang, Yajun Xiong, Zhihan Liu, Xiaoyong Song, Jiaojiao Liu, Yanli Gong, Zhuanzhuan Li, Xinli Shi   +7 more
doaj   +1 more source