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Tumor-infiltrating lymphocytes: A new hope
Cancer CellTumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik +3 more
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Tumor-Infiltrating Lymphocytes
The Cancer Journal, 2015Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with lymphodepletion and high-dose interleukin 2 has shown reproducible objective response rates of approximately 50% in patients with highly advanced, refractory metastatic melanoma.
Michal J, Besser +2 more
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Annals of Surgery, 2020
OBJECTIVE To determine whether prognostic nutritional index (PNI) affects clinical outcome through local immunity in esophageal cancers. BACKGROUND PNI is an indicator of nutritional status and systemic immune competence, and has attracted attention as
K. Okadome +9 more
semanticscholar +1 more source
OBJECTIVE To determine whether prognostic nutritional index (PNI) affects clinical outcome through local immunity in esophageal cancers. BACKGROUND PNI is an indicator of nutritional status and systemic immune competence, and has attracted attention as
K. Okadome +9 more
semanticscholar +1 more source
Tumor microenvironment and lymphocyte infiltration
Cancer Immunology, Immunotherapy, 2012There is ample evidence that the presence of tumor-infiltrating T lymphocytes is associated with a favorable prognostic in patients. These observations suggest that a limiting step to immune resistance and immunotherapy could be the capacity of tumor-specific T cells to reach tumor bed.
Rahir, Gwendoline, Moser, Muriel
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Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer.
Journal of the American Medical Association (JAMA)Importance The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant ...
R. Leon-Ferre +32 more
semanticscholar +1 more source
Clonal dynamics of tumor-infiltrating lymphocytes
European Journal of Immunology, 2005The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Rong, Yu +4 more
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Tumor-Infiltrating Lymphocyte Therapy
The Cancer Journal, 2015Autologous adoptive T-cell therapies have made tremendous strides over the last few years with excitement currently being generated by technologies that can reprogram T-cell specificities toward any desired antigen including chimeric antigen receptors and recombinant T-cell receptors.
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