Results 61 to 70 of about 2,902,083 (309)

A novel clinical model for predicting malignancy of solitary pulmonary nodules: a multicenter study in chinese population

Cancer Cell International, 2021
Background This study aimed to establish and validate a novel clinical model to differentiate between benign and malignant solitary pulmonary nodules (SPNs).
Xia He, Ning Xue, Xiaohua Liu, Xuemiao Tang, Songguo Peng, Yuanye Qu, Lina Jiang, Qingxia Xu, Wanli Liu, Shulin Chen   +9 more
doaj   +1 more source

Targeted transgenic RNAi knockdown of cell fate determinants induces neoplastic tumor growth and metastasis in a Drosophila transplantation model of neural stem cell derived cancer [PDF]

, 2012
Genetic models such as Drosophila have sophisticated transgenic and molecular genetic tools available to investigate proliferation control in normal and tumorigenic neural stem cells.
Reichert, Heinrich, Laurenson, Anne-Sophie, Saini, Nidhi, Jiang, Yanrui   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Prognostic value of chromogranin A in patients with GET/NEN in the pancreas and the small intestine

Endocrine Connections, 2018
The aim of this study was to evaluate the clinical usefulness of the chromogranin A (CgA) determination in patients with neuroendocrine neoplasms (NENs) of the digestive system and to analyse the association between concentration of the marker and ...
Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, Beata Kotowicz   +7 more
doaj   +1 more source

In-situ Formation of Amorphous Co-Al-P Layer on CoAl Layered Double Hydroxide Nanoarray as Neutral Electrocatalysts for Hydrogen Evolution Reaction

Frontiers in Chemistry, 2020
Exploration of high-efficiency and inexpensive electrode catalysts is of vital importance for the hydrogen evolution reaction (HER). In this research, an amorphous Co-Al-P layer was constructed on the surface of CoAl layered double hydroxide (CoAl-LDH ...
Wanqing Teng, Zhaomei Sun, Zhaomei Sun, Junfeng Xie, Ziqiang Wang, Xiangjiang Zheng, Bo Tang   +6 more
doaj   +1 more source

Tumor associated antigens in diagnosis of serous effusions [PDF]

, 1988
The use of tumour associated antigens in the diagnosis of serous effusions was studied in 76 patients with benign and 200 patients with malignant disease.
Permanetter, W., Mezger, J., Lamerz, Rolf, Wilmanns, W., Gerbes, Alexander L.   +4 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Elevated Levels of sLAG-3 as a Possible Biomarker in Graves’ Disease With and Without Thyroid Eye Disease: A Prospective Observational Case–Control Study

Medicina
Background and Objectives: The pathogenesis of thyroid eye disease (TED) is driven by interactions between orbital fibroblasts and immune cells. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint molecule with a similar structure to the T ...
Katarzyna Cieplińska, Emilia Niedziela, Edyta Jagielska, Iwona Pałyga, Anna Słuszniak, Aldona Kowalska   +5 more
doaj   +1 more source

Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]

, 2011
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde, Lavanya Suneetha, Karuna Devi, Wim H. van Brakel, Shinde, V., Suneetha Lavanya, Diana N J Lockwood, Jadhav, Rupendra, Nicholls Peter G., Peter G Nicholls, Chaduvula Meher Vani, Suneetha, L., Kamble Ravindra, Devi, K., Raju, Renuka, Jadhav Rupendra, Devi Karuna, Peter G. Nicholls, Diana N. J. Lockwood, Kamble, Ravindra, Lockwood, Diana NJ, Jadhav, R., Chaduvula, M.V., Suneetha, Sujai, Lockwood, D.N.J., Suneetha Sujai, Suneetha, Lavanya, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Raju, R., Suneetha, S., Devi, Karuna, Sujai Suneetha, Nicholls, Peter G, Kamble, R., Lockwood Diana N. J., Rupendra Jadhav, Nicholls, P.G., Shinde, Vidyagouri, Chaduvula, Meher Vani, Shinde Vidyagouri, van Brakel, W.H., Raju Renuka, Renuka Raju, Ravindra Kamble, Meher Vani Chaduvula   +46 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source