Results 71 to 80 of about 1,254,090 (295)

Prognostic value of chromogranin A in patients with GET/NEN in the pancreas and the small intestine

Endocrine Connections, 2018
The aim of this study was to evaluate the clinical usefulness of the chromogranin A (CgA) determination in patients with neuroendocrine neoplasms (NENs) of the digestive system and to analyse the association between concentration of the marker and ...
Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, Beata Kotowicz   +7 more
doaj   +1 more source

A new approach to epithelial–mesenchymal transition diagnostics in epithelial tumors: double immunofluorescent staining and flow cytometry

BioTechniques, 2020
A new method of double immunofluorescent staining for flow cytometry has been created to evaluate quantitative expression of mesenchymal protein vimentin only in epithelial cells of a solid tumor that is a mix of different origin cells.
Tatiana A Bogush, Anna A Basharina, Baina K Eliseeva, Sergey A Kaliuzhny, Elena A Bogush, Vladislav Y Kirsanov, Mikhail M Davydov, Vyacheslav S Kosorukov   +7 more
doaj   +1 more source

A novel clinical model for predicting malignancy of solitary pulmonary nodules: a multicenter study in chinese population

Cancer Cell International, 2021
Background This study aimed to establish and validate a novel clinical model to differentiate between benign and malignant solitary pulmonary nodules (SPNs).
Xia He, Ning Xue, Xiaohua Liu, Xuemiao Tang, Songguo Peng, Yuanye Qu, Lina Jiang, Qingxia Xu, Wanli Liu, Shulin Chen   +9 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In-situ Formation of Amorphous Co-Al-P Layer on CoAl Layered Double Hydroxide Nanoarray as Neutral Electrocatalysts for Hydrogen Evolution Reaction

Frontiers in Chemistry, 2020
Exploration of high-efficiency and inexpensive electrode catalysts is of vital importance for the hydrogen evolution reaction (HER). In this research, an amorphous Co-Al-P layer was constructed on the surface of CoAl layered double hydroxide (CoAl-LDH ...
Wanqing Teng, Zhaomei Sun, Zhaomei Sun, Junfeng Xie, Ziqiang Wang, Xiangjiang Zheng, Bo Tang   +6 more
doaj   +1 more source

NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. [PDF]

, 2017
N-myc and STAT interactor (NMI) has been proved to bind to different transcription factors to regulate a variety of signaling mechanisms including DNA damage, cell cycle and epithelial-mesenchymal transition. However, the role of NMI in the regulation of
Chen, Yiming, Deng, Wuguo, Feng, Xu, Gao, Yue, Guo, Wei, Hao, Jiaojiao, Huang, Wenlin, Kang, Lan, Liao, Yina, Tang, Ranran, Wu, Jiali, Xiao, Xiangsheng, Xu, Xiangdong, Yu, Wendan, Zhao, Xinrui, Zou, Kun   +15 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Elevated Levels of sLAG-3 as a Possible Biomarker in Graves’ Disease With and Without Thyroid Eye Disease: A Prospective Observational Case–Control Study

Medicina
Background and Objectives: The pathogenesis of thyroid eye disease (TED) is driven by interactions between orbital fibroblasts and immune cells. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint molecule with a similar structure to the T ...
Katarzyna Cieplińska, Emilia Niedziela, Edyta Jagielska, Iwona Pałyga, Anna Słuszniak, Aldona Kowalska   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source