Results 181 to 190 of about 3,570,297 (401)

Metabolic programming and immune suppression in the tumor microenvironment.

Cancer Cell, 2023
Emily N. Arner, J. Rathmell
semanticscholar   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Inflammation in the Tumor Microenvironment [PDF]

Journal of Immunology Research, 2018
Qing Lin, Shi Jin, Mei Han, Wenxin Zheng, Jiaming Liu, Xiaolong Wei   +5 more
openaire   +4 more sources

Relationship of mTORC1 and ferroptosis in tumors

Discover Oncology
Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid peroxidation. In recent years, ferroptosis has gained more and more interest of people in the treatment mechanism
Huilin Liao, Yueqing Wang, Lili Zou, Yanmei Fan, Xinyue Wang, Xiancong Tu, Qiaobai Zhu, Jun Wang, Xiaowen Liu, Chuanjiang Dong   +9 more
doaj   +1 more source

Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses [PDF]

, 2004
Paulo C. Rodrı́guez, David Quiceno, Jovanny Zabaleta, Blair Ortiz, Arnold H. Zea, M. Blanca Piazuelo, Alberto Delgado, Pelayo Correa, Jason Brayer, Eduardo M. Sotomayor, Scott Antonia, Juan B. Ochoa, Augusto C. Ochoa   +12 more
openalex   +1 more source

Spatial profiling technologies illuminate the tumor microenvironment.

Cancer Cell, 2023
O. Elhanani, R. Ben-Uri, Leeat Keren
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Nicotine Induced Lung Cancer Cells Epithelial-mesenchymal Transition 
and Promote Its Vitro Invasion Potential

Chinese Journal of Lung Cancer, 2016
Background and objective Our previous study found that nicotine could induce lung cancer cell epithelial-mesenchymal transition (EMT). The aim of this study is to explore the relationship between nicotine-induced EMT and lung cancer invasion and ...
Yanxu HOU, Xuebing LI, Zhenhua PAN, Lingling ZU, Yaguang FAN, Jiacong YOU, Yuli WANG, Min WANG, Peirui CHEN, Wang SHEN, Qinghua ZHOU   +10 more
doaj   +1 more source

Effect of Tumor Host Microenvironment on Photodynamic Therapy in a Rat Prostate Tumor Model [PDF]

, 2005
Bin Chen, Brian W. Pogue, Xiaodong Zhou, Julia A. O′Hara, Nicolas Solban, Eugene Demidenko, P. Jack Hoopes, Tayyaba Hasan   +7 more
openalex   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source