Results 221 to 230 of about 604,511 (258)
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Developmental & Comparative Immunology, 2004
Since the discovery of tumor necrosis factor (TNF) and lymphotoxin, many structurally related factors have been elucidated in mammals that are grouped together in the TNF Ligand Superfamily. These factors have profound pleiotropic roles involving inflammation, apoptosis, cell proliferation and stimulation of the immune system.
Frederick W, Goetz +2 more
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Since the discovery of tumor necrosis factor (TNF) and lymphotoxin, many structurally related factors have been elucidated in mammals that are grouped together in the TNF Ligand Superfamily. These factors have profound pleiotropic roles involving inflammation, apoptosis, cell proliferation and stimulation of the immune system.
Frederick W, Goetz +2 more
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Tumor Necrosis Factor and Anti-Tumor Necrosis Factor Therapies
The Journal of Rheumatology Supplement, 2010Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states.
Edward C, Keystone, Carl F, Ware
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Tumor necrosis factors in 1996
Cytokine & Growth Factor Reviews, 1996The 6th International Congress on Tumor Necrosis Factors and Related Molecules was held in Faliraki, Island of Rhodes, Greece, 8-12 May, 1996. This review summarizes the topics addressed and highlights some of the major advances presented during the meeting.
K, Pfizenmaier, H, Wajant, M, Grell
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Scientific American, 1988
A century ago it was noted that a bacterial infection sometimes causes the regression of cancer. In 1975 the author found an explanation: the infection stimulates the secretion of tumor necrosis factor (TNF), which has anticancer activity. Now TNF, an important regulator of inflammation and immunity, is in clinical trials as an anticancer drug.
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A century ago it was noted that a bacterial infection sometimes causes the regression of cancer. In 1975 the author found an explanation: the infection stimulates the secretion of tumor necrosis factor (TNF), which has anticancer activity. Now TNF, an important regulator of inflammation and immunity, is in clinical trials as an anticancer drug.
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Tumor necrosis: factors and principles
Immunology Today, 1996Abstract Tumor necrosis is often caused by vasculature shutdown, and the exploitation of altered features of the vasculature within solid tumors may give rise to novel forms of therapy. A recent meeting ∗ ∗The symposium ‘Tumor Necrosis: Factors and Principles' was held at Ringberg, Germany, on 29 October–1 November 1995.
D, Männel +3 more
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Seminars in Surgical Oncology, 1989
AbstractTumor necrosis factor (TNF) is a well‐described and characterized cytokine which can be elicited in the intact animal by endotoxin. This factor produces necrosis of subcutaneous tumors in the classic model: Meth A sarcoma in the Balb C mouse. It has been shown to be cytostatic or cytotoxic for a variety of human cancer cell lines, as well as to
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AbstractTumor necrosis factor (TNF) is a well‐described and characterized cytokine which can be elicited in the intact animal by endotoxin. This factor produces necrosis of subcutaneous tumors in the classic model: Meth A sarcoma in the Balb C mouse. It has been shown to be cytostatic or cytotoxic for a variety of human cancer cell lines, as well as to
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Tumor Necrosis Factor and Obesity
Annals of Internal Medicine, 1989Excerpt To the Editor:Although its role is not fully known, tumor necrosis factor (TNF) or cachectin would appear to be involved in determining nutritional status.
S, Chollet-Martin +3 more
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Tumor necrosis factor and the therapeutic potential of anti-tumor necrosis factor antibodies
Critical Care Medicine, 1993To review the relationship of tumor necrosis factor (TNF) to clinical sepsis and the clinical potential of anti-TNF therapy in decreasing morbidity and mortality rates due to sepsis.The international English language literature was reviewed, including animal studies and human clinical trials regarding TNF, anticytokine therapy, and sepsis.Studies which
J C, Wherry +2 more
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Tumor Necrosis Factor in Humans
New England Journal of Medicine, 1988When immune cells are stimulated in a variety of ways, they release soluble proteins called cytokines.
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The Pathophysiology of Tumor Necrosis Factors
Annual Review of Immunology, 1992Tumor necrosis factor (TNF) came to birth in a strange way. It made its entry into the world of biology and medicine when Lloyd Old discovered that the capacity to induce, in vivo and in vitro, the necrosis of some mouse tumors could be ascribed to a factor (rapidly identified as a protein) present in the blood after LPS injection ( 1 ) . Then, at what
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