Results 21 to 30 of about 725,440 (353)

Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]

, 1999
During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Kelly, Ralph A., Stefan Zahler, Habazettl, Helmut, Goedecke, Axel, Becker, Bernhard F., Dieter A. Wolf, Christian Kupatt, Helmut Habazettl, Boekstegers, Peter, Bernhard F. Becker, Kupatt, Christian, Peter Boekstegers, Zahler, Stefan, Wolf, Dieter A., Ralph A. Kelly, Axel Goedecke   +15 more
core   +1 more source

Tumor necrosis factor as a pharmacological target [PDF]

Molecular Biotechnology, 2004
As indicated by its name, tumor necrosis factor (TNF), cloned in 1985, was originally described as a macrophage-derived endogenous mediator that can induce hemorrhagic necrosis of solid tumors and kill some tumor cell lines in vitro. Unfortunately, its promising use as an anticancer agent was biased by its toxicity, which was clear soon from the first ...
Ghezzi, Pietro, Cerami, Anthony
openaire   +3 more sources

Locally up-regulated lymphotoxin a, not systemic tumor necrosis factor a, is the principle mediator of murine cerebral malaria [PDF]

, 2002
Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-{alpha} has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin {alpha} (LT{alpha}) in CM has been overlooked.
Sanjeet Sawhney, Mynott, T.L., Kaye, PM, De Souza, J Brian, Bickle, Quentin D, Kaye, P.M., Engwerda, C.R., Sawhney, Sanjeet, Engwerda, CR, Tracey L. Mynott, Paul M. Kaye, Christian R. Engwerda, Bickle, Q.D., Sawhney, S, Bickle, QD, Mynott, Tracey L, De Souza, JB, Mynott, TL, Engwerda, Christian R, Sawhney, S., J. Brian De Souza, Quentin D. Bickle, Kaye, Paul M, De Souza, J.B.   +23 more
core   +1 more source

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

Scientific Reports, 2017
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A. Eisler, Nathalie Peters, John R. Bethea, Klaus Pfizenmaier, Roland E. Kontermann   +7 more
doaj   +1 more source

Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer’s disease puzzle

Neural Regeneration Research, 2019
Due to the aging of the population and despite the enormous scientific effort, Alzheimer’s disease remains one of the biggest medical and pharmaceutical challenges in current medicine.
Sophie Steeland, Roosmarijn E Vandenbroucke   +1 more
doaj   +1 more source

The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-alpha [PDF]

, 2002
Heparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, is implicated in a variety of biological processes, including reproduction.
Mardon, Helen J., Yoo, Hyung-J, Katya Chobotova, Barlow, David, Helen J. Mardon, Carver, J, Chobotova, K, Muchmore, ME, William J. Gullick, Muchmore, Mary-Elizabeth, Chobotova, Katya, Janet Carver, Yoo, HJ, Hyung-J Yoo, David H. Barlow, Manek, Sanjiv, Sanjiv Manek, Manek, S, Barlow, DH, Mary-Elizabeth Muchmore, Gullick, WJ, Gullick, William J., Carver, Janet, Mardon, HJ   +23 more
core   +1 more source

Understanding the immunopathogenic bases and the clinical approach of the periodic syndrome associated with the tumor necrosis receptor, TRAPS

Iatreia, 2018
Tumor necrosis factor receptor periodic syndrome (TRAPS) is characterized by episodes of fever of more than 10 days of duration, migratory myalgias, pseudocellulitis, abdominal pain and bipalpebral edema.
Moreno Zuluaga, Catalina, Velásquez Lopera, Margarita María   +1 more
doaj   +1 more source

Interference of tumor necrosis factor inhibitor treatments on soluble tumor necrosis factor receptor 2 levels in rheumatoid arthritis

Practical Laboratory Medicine, 2019
Objective: Soluble Tumor Necrosis Factor Receptor II (sTNFR2) is used as a biomarker to study cardiovascular disease (CVD) in diverse populations. TNF inhibitors (TNFi's) are a common treatment for inflammatory conditions. The objective of this study was
Nicole Yang, Jie Huang, Michelle Frits, Christine Iannaccone, Michael E. Weinblatt, Nader Rifai, Nancy Shadick, Gary Bradwin, Katherine P. Liao   +8 more
doaj   +1 more source

Listeria Cerebritis with Tumor Necrosis Factor Inhibition

Case Reports in Infectious Diseases, 2020
Background. Listeria monocytogenes is historically a central nervous system pathogen of consideration in the very young, very old, and immune suppressed. Diagnosis of Listeria is based on positive bodily fluid culture or PCR testing.
Eileen Reilly, Justin Hwang
doaj   +1 more source

miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1

Tumor Biology, 2017
Tumor necrosis factor receptor 1 is the main receptor mediating many tumor necrosis factor-alpha–induced cellular events. Some studies have shown that tumor necrosis factor receptor 1 promotes tumorigenesis by activating nuclear factor-kappa B signaling ...
Yiling Zhao, Fenghua Yang, Wenyuan Li, Chunyan Xu, Li Li, Lifei Chen, Yancui Liu, Ping Sun   +7 more
doaj   +1 more source