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Tumor Necrosis Factor Alpha Signaling and Organogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication.
Kai You +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 1989 Binding of peptide hormones to surface membrane receptors leads to the transcription of specific genes within relevant target cells. How these signals are transduced to alter gene expression is largely unknown, but this mechanism probably involves a ...
L Osborn, S L Kunkel, Gary J. Nabel
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Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease. [PDF]
Current Alzheimer Research, 2016 Alzheimer's disease (AD) affects an estimated 44 million individuals worldwide, yet no therapeutic intervention is available to stop the progression of the dementia.
B. Decourt, D. Lahiri, M. Sabbagh
semanticscholar +4 more sources
Tumor necrosis factor-alpha inhibitor treatment for sarcoidosis
Therapeutics and Clinical Risk Management, 2008 José Luis Callejas-Rubio, Lourdes López-Pérez, Norberto Ortego-CentenoUnit of Autoimmune Systemic Diseases, Hospital Clinico San Cecilio, Granada, SpainAbstract: Sarcoidosis is a chronic multisystem disease of unknown ...
José Luis Callejas-Rubio +2 more
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Tumor necrosis factor alpha in sleep regulation.
Sleep Medicine Reviews, 2017 This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity. Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous brain TNF respectively promotes and inhibits sleep.
M. Rockstrom +6 more
semanticscholar +6 more sources
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
Mediators of Inflammation, 2014 Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
Gabriel Olmos, Jerònia Lladó
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Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha
Indian Journal of Ophthalmology, 2012 Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively
Renu Agarwal, Puneet Agarwal
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Tumor necrosis factor-alpha in patients with alopecia areata
Indian Journal of Dermatology, 2011 Background : Alopecia areata (AA) is a common form of localized, nonscarring hair loss. It is characterized by the loss of hair in patches, total loss of scalp hair (alopecia totalis, AT), or total loss of body hair (alopecia universalis, AU).
Emina Kasumagic-Halilovic +2 more
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Tumor necrosis factor alpha inhibits signaling from the insulin receptor. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1994 Insulin resistance is a common problem associated with infections and cancer and, most importantly, is the central component of non-insulin-dependent diabetes mellitus.
Gökhan S. Hotamışlıgil +3 more
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Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1992 Tumor necrosis factor alpha (TNF alpha), a primary mediator of systemic responses to sepsis and infection, can be injurious to the organism when present in excessive quantities.
Kimberly J. Van Zee +5 more
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