Results 221 to 230 of about 666,626 (377)

Effects of recombinant human interleukin-6 alone and in combination with recombinant interleukin-1 alpha and tumor necrosis factor alpha on antibacterial resistance in mice [PDF]

, 1992
Charles J. Czuprynski, Mary Haak‐Frendscho, N Maroushek, J F Brown   +3 more
openalex   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Conducting a real-world study of Tumor Necrosis factor-alpha inhibitors-induced Systemic Lupus Erythematosus based on the FAERS database. [PDF]

Sci Rep
He M, Yang J, Yan S, Shu Q, Liu PC.
europepmc   +1 more source

Role of protein kinase C activity in tumor necrosis factor-alpha gene expression. Involvement at the transcriptional level.

, 1992
Il Yup Chung, Jongbum Kwon, Etty Benveniste   +2 more
openalex   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Transcriptional Activity of Tumor Necrosis Factor Alpha Genes and Their Receptors in Patients with Varying Degrees of Coronary Artery Disease. [PDF]

Int J Mol Sci
Potyka K, Dąbek J.
europepmc   +1 more source

Unraveling the Role of Tumor Necrosis Factor-Alpha in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis. [PDF]

Cureus, 2023
Sen A, Mohanraj PS, Ranjan A, Rajendran V, ArulVijayaVani S, Balan Y, Bansal A.   +6 more
europepmc   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha: Ally and Enemy in Protean Cutaneous Sceneries. [PDF]

Int J Mol Sci
Pocino K, Carnazzo V, Stefanile A, Basile V, Guerriero C, Marino M, Rigante D, Basile U.   +7 more
europepmc   +1 more source

Gene sequence of feline tumor necrosis factor alpha

Nucleic Acids Research, 1990
Clarence A. Rawlings, Bradford W. Coffee, R A McGraw, Cynthia M. Otto, Roman T. Drews   +4 more
openaire   +4 more sources