Results 21 to 30 of about 729,544 (396)

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

Journal of Experimental Medicine, 1994
Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic ...
F. Sallusto, A. Lanzavecchia
semanticscholar   +1 more source

The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat [PDF]

, 2016
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse ...
Beattie, Elisabeth, Delles, Christian, Graham, Delyth, Guzik, Tomasz, Morgan, Hannah, Nosalski, Ryszard, Small, Heather Yvonne   +6 more
core   +1 more source

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]

, 2012
BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza, Beloosesky, Ron, Boles, Julie L, Desai, Mina, Ross, Michael G   +4 more
core   +1 more source

Role of tumor necrosis factor-α and its receptors in diesel exhaust particle-induced pulmonary inflammation [PDF]

, 2017
Inhalation of diesel exhaust particles (DEP) induces an inflammatory reaction in the lung. However, the underlying mechanisms remain to be elucidated. Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine that operates by binding to tumor
Boon, Louis, Joos, Guy, Kumar, Smitha, Maes, Tania, Provoost, Sharen, Tournoy, Kurt   +5 more
core   +3 more sources

Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis

Journal of the American College of Cardiology, 2000
We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis.Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha ...
Satoh, Mamoru, Nakamura, Motoyuki, Satoh, Hidetoshi, Saitoh, Hidenori, Segawa, Ikuo, Hiramori, Katsuhiko   +5 more
openaire   +2 more sources

Alopecia secondary to anti-tumor necrosis factor-alpha therapy [PDF]

Anais Brasileiros de Dermatologia, 2015
Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti ...
Lara Beatriz Prata Ribeiro, Juliana Carlos Gonçalves Rego, Bruna Duque Estrada, Paula Raso Bastos, Juan Manuel Piñeiro Maceira, Celso Tavares Sodré   +5 more
doaj   +1 more source

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

Journal of Biological Chemistry, 1991
The regulation by tumor necrosis factor alpha (TNF) of its own promoter has been investigated by transient transfection and nuclear protein binding assays. In human K652 erythroleukemia cells TNF produced an 8-10-fold activation of the human TNF promoter linked to the chloramphenicol acetyltransferase gene.
D C, Leitman, R C, Ribeiro, E R, Mackow, J D, Baxter, B L, West   +4 more
openaire   +2 more sources

Tumor Necrosis Factor Alpha-Mediated Asthma? [PDF]

International Archives of Allergy and Immunology, 2012
Thus the pathophysiology of allergic asthma is traditionally explained by mast celland/or Th2 cell-mediated airway inflammation, which is a manifestation of the acquired immune response. On the other hand, recent studies have identified various other important molecules associated with phenotypes of asthma, including tumor necrosis factor (TNF)[2, 3] ,
openaire   +2 more sources

Development of low blood glucose readings in nine non-diabetic patients treated with tumor necrosis factor-alpha inhibitors: a case series

Journal of Medical Case Reports, 2012
Introduction Treatment with various biological agents in disease states such as rheumatoid arthritis has been associated with multiple side effects. Whereas many of these are frequently reported in the literature, hypoglycemia, a possible side effect of ...
Czajkowska Jadwiga B, Shutty Brandon, Zito Susan   +2 more
doaj   +1 more source

Viewpoint on handling anti-TNF failure in psoriasis [PDF]

, 2013
An association among the occurrence of antidrug antibodies (ADAs), diminished trough serum drug levels (TSDLs) and non-response or loss of response has been described for several tumor necrosis factor alpha (TNF) blocking agents in a variety of diseases,
BRACKE, STEFANIE, Lambert, Jo
core   +1 more source